Results 61 to 70 of about 696,109 (263)
Blockchain: A Tale of Two Applications
Applied Sciences, 2018 Bitcoin continues to get more and more attention from the media, mainly because of the volatility of its value and insignificantly associated with the technological innovation.
Micael Ferreira +3 more
doaj +1 more source
Proofs of Proofs of Work with Sublinear Complexity
, 2016 In the setting of blockchain based transaction ledgers we study the problem of “simplified payment verification” (SPV) which refers to the setting of a transaction verifier that wishes to examine the last k blocks of the blockchain (e.g., for the purpose of verification of a certain transaction) using as only advice the genesis block (or some ...
Kiayias, A., Lamprou, N., Stouka, A.-P.
openaire +2 more sources
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
THE USE OF BLOCKCHAINS. AN R APPROACH [PDF]
Challenges of the Knowledge Society, 2018 The cryptocurrency is a hot topic and understanding the blockchain is very important. Also, understanding what blockchain may lead to more decentralized services and applications to be used, not only in relation to financial applications.
Nicolae-Marius JULA, Nicoleta JULA
doaj
Pricing Security in Proof-of-Work Systems
CoRR, 2020 A key component of security in decentralized blockchains is proof of opportunity cost among block producers. In the case of proof-of-work (PoW), currently used by the most prominent systems, the cost is due to spent computation. In this paper, we characterize the security investment of miners in terms of its cost in fiat money.
George Bissias +3 more
openaire +3 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
A Crypto Yield Model for Staking Return
FinTechWe introduce a model that derives a metric to answer the question: what is the expected gain of a staker? We calculate the rewards as the staking return in a Proof-of-Stake (PoS) consensus context.
Julien Riposo, Maneesh Gupta
doaj +1 more source
ASIC-Resistance of Multi-Hash Proof-of-Work Mechanisms for Blockchain Consensus Protocols
IEEE Access, 2018 Blockchain technology rapidly gained popularity based on its open and decentralized operation. Consensus protocol is the core mechanism of a blockchain network that securely maintains the distributed ledger from possible attacks from adversaries.
Hyungmin Cho
doaj +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source