Results 51 to 60 of about 696,109 (263)

On Some Approaches to the Solution of the Problem «Useful Proof-of-work for Blockchains»

open access: yesМоделирование и анализ информационных систем, 2018
The blockchain technology is based on the ”Proof-of-work” principles. The essence of this principle is that some event (for example the bill-to-bill money transaction) becomes significant after the confirmation by a certain computer work.
Valeriy G. Durnev   +3 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

HealthDote: A blockchain-based model for continuous health monitoring using interplanetary file system

open access: yesHealthcare Analytics, 2023
The Healthcare industry demands increased privacy and security to protect confidential patient information and comply with regulations. Both these features can be incorporated into the existing systems using Blockchain technology.
Sireejaa Uppal   +3 more
doaj   +1 more source

Energy Equilibria in Proof-of-Work Mining [PDF]

open access: yesProceedings of the 2019 ACM Conference on Economics and Computation, 2019
The Bitcoin protocol induces miners, through monetary rewards, to expend energy in order to add blocks to the chain. We show that, when energy costs are substantial and taken into account, counterintuitive and unintended strategic behavior results: In a simple bounded-horizon setting with two identical miners there is a unique pure symmetric ...
Amos Fiat   +3 more
openaire   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

THE IMPACT OF ENERGY CONSUMPTION IN CRYPTO ASSETS ON CRYPTO ASSET PRICES AND CARBON EMISSIONS: CASE OF BITCOIN AND ETHEREUM [PDF]

open access: yesFinancial Studies
In this paper, it is aimed to evaluate the relationship between energy consumption in crypto assets and crypto asset prices. In this direction, the price, CO2 emission and energy consumption series of Bitcoin and Ethereum between March 17, 2021, and ...
Meltem BİLİRER, Feyyaz ZEREN
doaj  

SoK of Used Cryptography in Blockchain

open access: yesIEEE Access, 2019
The underlying fundaments of blockchain are cryptography and cryptographic concepts that provide reliable and secure decentralized solutions. Although many recent papers study the use-cases of blockchain in different industrial areas, such as finance ...
Mayank Raikwar   +2 more
doaj   +1 more source

Proof of Work With External Utilities

open access: yesCoRR
Proof-of-Work (PoW) consensus is traditionally analyzed under the assumption that all miners incur similar costs per unit of computational effort. In reality, costs vary due to factors such as regional electricity cost differences and access to specialized hardware.
Yogev Bar-On   +2 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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