Results 41 to 50 of about 696,109 (263)

Proof-of-Work as a Stigmergic Consensus Algorithm

International Joint Conference on Autonomous Agents and Multiagent Systems, 2022
In this paper, we make a theoretical analysis from a coordination perspective and conclude that the Proof-of-Work (PoW) algorithm is a stigmergic consensus algorithm where the trace left by an action in the blockchain through indirect coordination of agents stimulates subsequent actions and eventually creates a single chain of blocks.
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Coin.AI: A Proof-of-Useful-Work Scheme for Blockchain-Based Distributed Deep Learning

Entropy, 2019
One decade ago, Bitcoin was introduced, becoming the first cryptocurrency and establishing the concept of “blockchain” as a distributed ledger.
Alejandro Baldominos, Yago Saez
doaj   +1 more source

Cryptocurrencies: Miner Heterogeneity, Botnets, and Proof-of-Work Efficiency

Frontiers in Blockchain, 2020
Proof-of-work cryptocurrencies are heavily criticized for the alleged inefficiency of their mining mechanism. However, critics fail to distinguish between the resources that are used to secure the blockchain and those that are wasted.
Fabian Schär
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Equihash: Asymmetric Proof-of-Work Based on the Generalized Birthday Problem

Ledger, 2017
Proof-of-work is a central concept in modern cryptocurrencies and denial-ofservice protection tools, but the requirement for fast verification so far has made it an easy prey for GPU-, ASIC-, and botnet-equipped users.
Alex Biryukov, Dmitry Khovratovich
doaj   +1 more source

On the Storage Overhead of Proof-of-Work Blockchains

2022 IEEE International Conference on Blockchain (Blockchain), 2022
Permissionless blockchains such as Bitcoin have long been criticized for their high computational and storage overhead. Unfortunately, while a number of proposals address the energy consumption of existing Proof-of-Work deployments, little attention has been given so far to remedy the storage overhead incurred by those blockchains.
Alessandro Sforzin, Matteo Maso, Claudio Soriente, Ghassan Karame   +3 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source