Results 41 to 50 of about 460,569 (242)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Flying Target Detection Technology Based on GNSS Multipath Signals

Sensors
In this study, a passive radar system that detects flying targets is developed in order to solve the problems associated with traditional flying target detection systems (i.e., their large size, high power consumption, complex systems, and poor ...
Pengfei Zhu, Qinglin Zhu, Xiang Dong, Mingchen Sun   +3 more
doaj   +1 more source

Statistical Study of Ionospheric Equivalent Slab Thickness at Guam Magnetic Equatorial Location

Remote Sensing, 2021
The ionospheric equivalent slab thickness (τ) is defined as the ratio of the total electron content (TEC) to the F2-layer peak electron density (NmF2), and it is a significant parameter representative of the ionosphere.
Yuqiang Zhang, Zhensen Wu, Jian Feng, Tong Xu, Zhongxin Deng, Ming Ou, Wen Xiong, Weimin Zhen   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Determining Wind Shear Threshold by Using Historical Sounding Data in Experimental Area

Atmosphere
This paper conducts a technical study on a method for determining the occurrence threshold of wind shear based on historical sounding data. After analyzing the impact of low-altitude wind shear on aircraft flight safety, a method for determining the ...
Tingting Shu, Qinglin Zhu, Xiang Dong, Houcai Chen, Leke Lin, Xuan Liu   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

PAINLEV´E TEST OF A MAGNETOHYDRODYNAMICS SYSTEM [PDF]

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki, 2015
One approximation of magnetohydrodynamics equations, which describe the cosmic object’s magnetic field, is considered. The analytic properties of a nonlinear system are investigated by Painlev´e test.
G.M. Vodinchar, D.S. Noshenko, A.S. Perezhogin   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Progress and prospects based on Qujing incoherent scatter radar measurements

地球与行星物理论评
Herein, the technical characteristics and programme of Qujing incoherent scatter radar (the first one in China) are described. The measurement ability in the ionosphere, space debris, and the Moon was investigated using the data.
Jiansu Miao, Zonghua Ding, Liandong Dai, Song Yang, Jian Wu   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source