Results 51 to 60 of about 2,073,215 (262)

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

A Generalisation of the Signal‐to‐Noise Ratio Using Proper Scoring Rules

Meteorological Applications
A generalised concept of the signal‐to‐noise ratio (SNR) (or equivalently the ratio of predictable components, or RPC) is provided, based on proper scoring rules.
Jochen Bröcker, Eviatar Bach
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Domination for Finite Proper Scoring Rules [PDF]

, 2023
Scoring rules measure the deviation between a forecast, which assigns degrees of confidence to various events, and reality. Strictly proper scoring rules have the property that for any forecast, the mathematical expectation of the score of a forecast $p$
Pruss, Alexander
core  

Characterization of the key membrane protein cytochrome Cyc2 from Ghiorsea bivora

FEBS Open Bio, EarlyView.
This study reports the first detailed biochemical analysis of Cyc2TAG1_1, a cytochrome protein involved in microbial iron oxidation. We produced and purified this enzyme in E. coli, then measured its iron‐oxidizing efficiency, and characterized its electrical and structural properties.
Josiane Azizi, Alain Dolla, Frauke Baymann, Celine Rommevaux, Latifa Elantak, Helene Gaussier, Matthieu Nouailler   +6 more
wiley   +1 more source

Incentive Schemes for Centralized Material Planning and Allocation With Asymmetric Information in Construction Supply Chain

IEEE Access
In construction projects, a centralized management mode can effectively address the material management issues. Specifically, the Material Management Department (MMD) is responsible for material purchase, storage, and allocation based on the demand ...
Hui Lu, Hongwei Wang, Chao Qi, Yong Xie, Dian Liu   +4 more
doaj   +1 more source

Eliciting beliefs: Proper scoring rules, incentives, stakes and hedging [PDF]

European Economic Review, 2013
Accurate measurements of probabilistic beliefs have become increasingly important both in practice and in academia. Introduced by statisticians in the 1950s to promote truthful reports in simple environments, Proper Scoring Rules (PSR) are now arguably the most popular incentivized mechanisms to elicit an agent’s beliefs.
Armantier, Olivier, Treich, Nicolas
openaire   +9 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

CreditR1: Calibration-Aware Reinforcement Learning for Interpretable Corporate Credit Risk Assessment with Large Language Models

Mathematics
Probability-of-default (PD) estimation under the Basel and IFRS 9 frameworks requires probabilities that are both discriminative and well-calibrated. Large language models applied to credit assessment via prompting or supervised fine-tuning (SFT) yield ...
Yuxuan Wu, Haowen Dai, Yiheng Zhang, Jinping Ma   +3 more
doaj   +1 more source