Results 121 to 130 of about 129,614 (305)

Propofol differentially inhibits the release of glutamate, γ-aminobutyric acid and glycine in the spinal dorsal horn of rats [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s): Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic that is commonly used for the general anesthesia. It is well known that the spinal cord is one of the working targets of general anesthesia including propofol. However, there is
Jing Yang, Wei Wang, Zheng Yong, Weidong Mi, Hong Zhang   +4 more
doaj  

Drug‐Induced Sleep Endoscopy Findings in Obese Adolescents With Sleep Apnea

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Data regarding drug‐induced sleep endoscopy (DISE) findings in obese adolescents with obstructive sleep apnea (OSA) are lacking; such information could be used to direct and improve management as there is controversy whether adenotonsillectomy (AT) or positive airway pressure is standard therapy for this population.
Timothy Kearney, Turaj Vazifedan, Cristina M. Baldassari   +2 more
wiley   +1 more source

Neuromuscular Monitoring of Rocuronium 0.6 mg/kg in Children Aged 3–24 Months With Electromyography and Acceleromyography: An Observational Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Objective neuromuscular monitoring is essential to prevent residual neuromuscular block in patients receiving neuromuscular blocking agents. However, the small size of pediatric hands and the lack of appropriately sized neuromuscular equipment have made quantitative neuromuscular monitoring at the ulnar nerve (UN) difficult. In such
Sarah Sofie Wadland, Karl Peter Damgård Madsen, Mikkel Helmuth Jensen, Magnus Fuhr Hovind, Morten Sonne, Morten Bøttger, Arash Afshari, Frederik Mondrup, Matias Vested   +8 more
wiley   +1 more source

Pharmacokinetics of Intravenous Melatonin in Preschool‐Aged Pediatric Surgical Patients

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Melatonin may have several beneficial clinical effects in the perioperative setting. In children, it has been studied for preoperative anxiety, postoperative pain, and emergence delirium. Melatonin's pharmacokinetic profile is well‐known in adults, but data in young children are sparse.
Anne Louise de Barros Garioud, Arash Afshari, Lau Romlund Halgreen, Kristian Østergaard Nielsen, Lars Peter Kloster Andersen   +4 more
wiley   +1 more source

Perianesthetic Complications in Genetic Mitochondrial Disease: A Review of Case Reports

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Genetic mitochondrial diseases (GMDs) are a large group of genetically and clinically heterogeneous disorders caused by defects in genes encoding mitochondrial components. GMDs are grouped into named syndromes based on clinical presentation, for example, Leigh syndrome (LS).
Brittany M. Johnson, Simon C. Johnson
wiley   +1 more source

Porous Baicalin-Fe(III) ICP@Propofol nanocomposites for enhanced anesthetic efficacy and reduced toxicity via neuroprotection and ultrasound assistance

Asian Journal of Pharmaceutical Sciences
To enhance the anesthetic efficacy of propofol while mitigating its systemic toxicity and irreversible developmental neurotoxicity, we developed a strategy leveraging the neuroprotective effects of baicalin in combination with propofol anesthesia via ...
Shuo Zhang, Lei Shi, Jiansheng He, Ji Xia, Shunlian Li, Rong Wang, Qingyan Ma, Mingting Zhu, Peng Tang, Hao Tian, Feiqian Wang, Mingxi Wan, Daocheng Wu, Wei Gao, Xiancang Ma, Feng Zhu   +15 more
doaj   +1 more source

Effects of Esketamine on Emergence Delirium in Children Undergoing Sevoflurane Anesthesia: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Emergence delirium is a frequent and distressing postoperative complication in children, particularly following sevoflurane‐based anesthesia. Despite its clinical importance, the optimal preventive strategy remains under investigation.
Munder Lateiresh, Abdelaziz Louat, Mukhtar Alwefati, Alhasan Altayf, Matthieu Legrand, Phillip D. Cohen, Eman Abdulwahed, Sapna R. Kudchadkar, Muhammed Elhadi   +8 more
wiley   +1 more source

Pre‐Extubation Low‐Dose Propofol in Pediatric Ear, Nose, and Throat Procedures: A Meta‐Analysis With Trial Sequential Analysis

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Post‐extubation emergence agitation (EA) is common in pediatric ear, nose, and throat (ENT) procedures and may lead to serious complications. Aims To assess the efficacy of low‐dose propofol administered before extubation, compared with placebo, for preventing EA, using meta‐analysis with trial sequential analysis (TSA).
Rafaela Silva, Raphaela Mendes, João Mario Borges, Henrique Pivetta, Rafael Miranda, Isabela Alles, Vinicius Oliveira, Steven Staffa, Walid Alrayashi   +8 more
wiley   +1 more source

Propofol addiction drives neuronal senescence and cognitive decline via autophagy-mediated ADAR1/SIRT1 disruption

Communications Biology
Propofol addiction represents a significant clinical challenge with no approved pharmacotherapy. While cognitive decline is a hallmark of substance use disorders, its underlying mechanisms in propofol addiction remain unclear.
Xidi Wang, Shounuo Lin, Zhiting Zou, Dan Zhu, Jiahui Zhou, Xiaoyu Zhang, Jianan Lv, Wenhua Zhou, Yu Liu, Zizhen Si   +9 more
doaj   +1 more source

A Sedation Protocol for Endoscopic Baton‐Plate Adjustment in Neonates With Pierre Robin Sequence

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Robin sequence (RS) is characterized by upper airway obstruction leading to life‐threatening desaturations in neonates. Procedural sedation in this population presents unique challenges due to anatomical airway anomalies, young patient age, and associated comorbidities.
Nicolas Leister, Sarah Achterrath, Uwe Trieschmann, Teresa Kruse, Bert Braumann, Volker C. Schick   +5 more
wiley   +1 more source