Results 101 to 110 of about 23,350,298 (259)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Advanced Survival Analysis of Iranian Lung Cancer Patients: Prospective Cohort Study of Prognostic Factors [PDF]

علوم بهداشتی ایران
Background and purpose: Addressing survival in lung cancer patients is crucial because it directly informs prognosis, guides personalized treatment strategies, and highlights disparities in healthcare access.
Mahmood Moosazadeh, Ali Asghar Nadi Ghara, Mobina Gheibi, Ghasem Janbabaei, Akbar Hedayatizadeh Omran, Reza Alizadeh-Navaei, Ramin Shekarriz, Ehsan Zaboli, Mohammad Eslami Jouybari, Erfan Ghadirzadeh   +9 more
doaj  

Quantization as Survival Analysis: Discrete-Time Proportional Hazards Models for Bit-Width Collapse Prediction

IEEE Access
Post-training quantization of large language models (LLMs) requires careful allocation of bit-widths across heterogeneous architectural components. Existing sensitivity metrics rely on gradient norms, Hessian traces, or activation ranges, all of which ...
Miavaka Voninahitra Ambinintsoa Rakotovao Valisoa, Hobihery Matio Robinson   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Constructing Area-Proportional Venn and Euler Diagrams with Three Circles [PDF]

, 2005
A 3-Venn diagram is used to represent all possible combinations of three characteristics and is most commonly drawn with three overlapping congruent circles.
Chow, Stirling, Rodgers, Peter
core  

Cox Proportional Hazards Model Analysis of Survival Among Tuberculosis Patients Under Treatment in Mbuji-Mayi, Democratic Republic of the Congo

Journal of Multidisciplinary Healthcare
Moise Kanyiki Katala,1 Michel Kabamba Nzaji,2,3 Félicien Ilunga Ilunga4 1Department of Epidemiology and Biostatistics, Higher Institute of Medical Techniques of Mbuji-Mayi, Mbuji-Mayi, Democratic Republic of Congo; 2Department of Public Health ...
Kanyiki Katala M, Kabamba Nzaji M, Ilunga Ilunga F   +2 more
doaj  

An economic analysis of leisure-proportional benefits in a small open economy

Public Sector Economics
This paper analyses the impact of public pensions on resource allocation in a small open economy. In particular, we focus on the economic implications of leisure-proportional benefits.
Wataru Kobayashi, Junichiro Takahata
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source