Results 151 to 160 of about 800,848 (376)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sure Joint Screening for High Dimensional Cox's Proportional Hazards Model Under the Case-Cohort Design. [PDF]

J Comput Biol, 2023
Liu Y, Li G.
europepmc   +1 more source

g12 – Survival Analysis g12zac [PDF]

nag_surviv_risk_sets (g12zac) nag_surviv_risk_sets (g12zac) creates the risk sets associated with the Cox proportional hazards model for fixed ...
Function Document, Nag C Library
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Penalized weighted proportional hazards model for robust variable selection and outlier detection. [PDF]

Stat Med, 2022
Luo B, Gao X, Halabi S.
europepmc   +1 more source

Assessing performance and clinical usefulness in prediction models with survival outcomes: practical guidance for Cox proportional hazards models

medRxiv, 2022
D. Mclernon, D. Giardiello, B. Calster, L. Wynants, N. Geloven, M. Smeden, T. Therneau, E. Steyerberg, Polwarth Building   +8 more
semanticscholar   +1 more source

YPmodelPhreg: The Short-Term and Long-Term Hazard Ratio Model with Proportional Adjustment [PDF]

, 2023
Daewoo Pak, Song Yang
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Prognostic analysis of breast cancer in Xinjiang based on Cox proportional hazards model and two-step cluster method. [PDF]

Front Oncol, 2022
Wu M, Zhao T, Zhang Q, Zhang T, Wang L, Sun G.   +5 more
europepmc   +1 more source