Results 121 to 130 of about 146,465 (290)

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Retrospective Evaluation of an Oral Propranolol Delivery Strategy in 25 Cases of Infantile Hemangioma

Journal of Plastic and Reconstructive Surgery
Objectives: The majority of infantile hemangiomas shrink on their own, but when there is a chance of functional impairment, ulceration, or aesthetic issues, an active therapeutic intervention is needed.
Shinichi Ashizawa, Takanobu Kan, Shunsuke Takahagi, Mikio Kawai, Sayuri Toda, Yasumasa Iwasaki, Shuhei Karakawa, Michihiro Hide, Akio Tanaka   +8 more
doaj  

Propranolol reduces viability and induces apoptosis in hemangioblastoma cells from von Hippel-Lindau patients

Orphanet Journal of Rare Diseases, 2015
BackgroundVon Hippel-Lindau (VHL) disease is a rare oncological disease with an incidence of 1:36,000, and is characterized by the growth of different types of tumors: hemangioblastomas in the central nervous system (CNS) and retina, renal carcinoma ...
Virginia Albiñana, K. Villar Gómez de las Heras, G. Serrano-Heras, T. Segura, A. Perona-Moratalla, Mercedes Mota-Pérez, J. D. de Campos, L. Botella   +7 more
semanticscholar   +1 more source

Polymer type effect on microparticle blend of ethyl cellulose, poly(lactic‐co‐glycolic acid) and poly(ε‐caprolactone) for controlled drug delivery with varying solubility

Polymer International, EarlyView.
Preparation, possible microparticles formed, morphology of microparticles and drug release profile from polymeric microparticles. Abstract The objective of this study was to investigate the impact of polymer type on polymeric microparticle blends designed for controlled drug delivery. Microparticle blends containing a single drug (propranolol HCl [Pro]
Muhaimin Muhaimin, Roland Bodmeier
wiley   +1 more source

Enhanced Retention In The Passive-Avoidance Task By 5-HT1A Receptor Blockade Is Not Associated With Increased Activity Of The Central Nucleus Of The Amygdala [PDF]

, 2003
The effect of blockade of S-HT1A receptors was investigated on (1) retention in a mildly aversive passive-avoidance task, and (2) spontaneous single-unit activity of central nucleus of the amygdala (CeA) neurons, a brain site implicated in modulation of ...
Everbach, E. Carr, Firestone, Aaron Alexander, , \u2701, Naylor, J. C., Schneider, Allen M., Simson, Peter E., , \u2778, Wilkins, Emily, , \u2701   +5 more
core   +1 more source

Haemodynamic effects of propranolol (Inderal) in acute myocardial infarction. [PDF]

, 1967
Gunnar Bay, Per G. Lund‐Larsen, E Lorentsen, E Sivertssen   +3 more
openalex   +1 more source

Propranolol represses infantile hemangioma cell growth through the β2-adrenergic receptor in a HIF-1α-dependent manner.

Oncology Report, 2015
Propranolol, as a non-selective blocker of the β-adrenergic receptor (AR), is utilised as the first-line treatment for infantile hemangiomas. However, the underlying mechanism remains poorly understood.
Peng Li, Zhengtuan Guo, Ya Gao, Weikang Pan   +3 more
semanticscholar   +1 more source

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu, Ian Sorrell, Fang Ma, Miaoran Ning, Yoen‐Ju Son, Gaohong She, Tom De Bruyn, Joshua Galanter, Nastya Kassir, Ryan Owen, Masoud Jamei, Iain Gardner, Yuan Chen   +12 more
wiley   +1 more source

The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias [PDF]

, 1968
A. M. Barrett, VALERIE A. CULLUM
openalex   +1 more source

Rifaximin‐α in Patients With Recurrent Episodes of Hepatic Encephalopathy Due to Cirrhosis Reduces Healthcare Utilization

United European Gastroenterology Journal, EarlyView.
ABSTRACT Background and Aims Hepatic encephalopathy is a frequent complication of cirrhosis. Rifaximin‐α has been included in guidelines for secondary prevention of hepatic encephalopathy, but there are few real‐world data on its efficacy and impact on healthcare utilization.
Diederick J. van Doorn, Kirsi. M. A. van Eekhout, Koos de Wit, L. C. Baak, Michael Klemt‐Kropp, Bart J. Verwer, Philip Friederich, Gijs J. de Bruin, Xander G. Vos, Joost P. H. Drenth, R. Bart Takkenberg   +10 more
wiley   +1 more source