Results 21 to 30 of about 148,383 (342)

Plasma Drug Concentration of Propranolol and Genetic Study in Chinese Han Patients With Infantile Haemangioma

Frontiers in Pediatrics, 2022
Background and PurposeThis study was conducted to explore the plasma drug concentration of propranolol in Chinese Han patients with infantile haemangioma (IH) and the influencing factors, as well as the relationship among plasma drug concentrations of ...
Li Li, Lu Yu, Huan He, Li Wei, Zigang Xu, Libo Zhao, Yujuan Sun, Bin Zhang, Yuanxiang Liu, Rui He, Xiaoling Wang, Lin Ma   +11 more
doaj   +1 more source

Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma

JAMA pediatrics, 2021
Key Points Question Is nadolol noninferior to propranolol in the management of infantile hemangioma? Findings In this randomized clinical trial, infantile hemangiomas treated with nadolol showed a larger change in size and color compared with propranolol,
E. Pope, I. Lara‐Corrales, C. Sibbald, C. Liy-Wong, N. Kanigsberg, B. Drolet, Jin Ma   +6 more
semanticscholar   +1 more source

Critical role of Aquaporin-1 and telocytes in infantile hemangioma response to propranolol beta blockade

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Although a role for β-adrenergic receptor (ADRB) in cancer progression was suggested a long time ago, our serendipitous observation of the propranolol efficacy in treating infantile hemangioma (IH) has driven attention in exploring the ...
F. Moisan, S. Oucherif, P. Kaulanjan-Checkmodine, S. Prey, B. Rousseau, M. Bonneu, S. Claverol, E. Gontier, S. Lacomme, L. Dousset, T. Couffinhal, J. Toutain, M. Loot, M. Cario-André, M. Jullie, C. Léauté-Labrèze, A. Taieb, H. Rezvani   +17 more
semanticscholar   +1 more source

Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis

Pharmaceutics, 2023
The effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments.
Venkatesh Mayandi, Wen-Tyng Kang, Darren Shu Jeng Ting, Eunice Tze Leng Goh, Myoe Naing Lynn, Thet Tun Aung, Jamuna Vadivelu, Veluchamy Amutha Barathi, Anita Sook Yee Chan, Rajamani Lakshminarayanan   +9 more
doaj   +1 more source

Propranolol Modulates Cerebellar Circuit Activity and Reduces Tremor

Cells, 2022
Tremor is the most common movement disorder. Several drugs reduce tremor severity, but no cures are available. Propranolol, a β-adrenergic receptor blocker, is the leading treatment for tremor. However, the in vivo circuit mechanisms by which propranolol
Joy Zhou, Meike E. Van der Heijden, Luis E. Salazar Leon, Tao Lin, Lauren N. Miterko, Dominic J. Kizek, Ross M. Perez, Matea Pavešković, Amanda M. Brown, Roy V. Sillitoe   +9 more
doaj   +1 more source

Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity

Clinical Cancer Research, 2020
Purpose: Increased β-adrenergic receptor (β-AR) signaling has been shown to promote the creation of an immunosuppressive tumor microenvironment (TME). Preclinical studies have shown that abrogation of this signaling pathway, particularly β2-AR, provides ...
S. Gandhi, M. Pandey, K. Attwood, Wenyan Ji, A. Witkiewicz, E. Knudsen, Cheryl L. Allen, J. Tario, P. Wallace, Carlos Cedeno, M. Levis, S. Stack, P. Funchain, J. Drabick, Mark J. Bucsek, I. Puzanov, H. Mohammadpour, E. Repasky, M. Ernstoff   +18 more
semanticscholar   +1 more source

Propranolol for the management of behavioural and psychological symptoms of dementia

Drugs in Context, 2022
Propranolol is a β-adrenergic antagonist used in the management of hypertension, cardiac arrhythmia, and angina pectoris. There is some evidence that propranolol may benefit individuals with behavioural and psychological symptoms of dementia (BPSD).
Rajesh R Tampi, Deena J Tampi, Deena J Tampi, Sochima I Ochije, Pallavi Joshi   +4 more
doaj   +1 more source

Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Scientific Reports, 2022
Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- and middle-income countries.
Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona   +7 more
doaj   +1 more source

The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens

Biomedicines, 2023
The development of bacterial resistance is an increasing global concern that requires discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems play important roles in controlling bacterial virulence, and their targeting ...
Hadil Faris Alotaibi, Haifa Alotaibi, Khaled M. Darwish, El-Sayed Khafagy, Amr S. Abu Lila, Mohamed A. M. Ali, Wael A. H. Hegazy, Samar Zuhair Alshawwa   +7 more
doaj   +1 more source

Successful and safe treatment of hemangioma with oral propranolol in a single institution [PDF]

Korean Journal of Pediatrics, 2012
PurposeDramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined.
Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo   +7 more
doaj   +1 more source