Results 81 to 90 of about 146,465 (290)

Combating cancer immunotherapy resistance: a nano‐medicine perspective

Cancer Communications, EarlyView.
Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong, Xintong Xie, Juan Wu, Xiangyu Wang, Wenxiang Zhang, Shuowen Wang, Daria Valerievna Abbasova, Yi Fang, Hongnan Jiang, Jidong Gao, Jing Wang   +10 more
wiley   +1 more source

The significance of hazardous chemicals in wastewater treatment works effluents [PDF]

, 2012
This is the post-print version of the final paper published in Science of The Total Environment. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Aquacheck Bury UK, Bedding, Bedding, Behera, Brian Ellor, Buisson, Comber, Comber, De Schamphelaere, Dodds, EC European Commission, EC European Commission, EC European Commission, EC European Commission, Elise Cartmell, Eriksson, Feldman, Gabriel, Gardner, Gardner, González, Hope, John Lester, Jones, Kendall, Kolpin, Lester, Lester, Mark D. Scrimshaw, Martin Ruel, Martínez Bueno, McAdam, McAdam, Michael Gardner, Musoleff, O’Reilly Wiese, O’Reilly Wiese, R Development Core Team, Robertson, Rodil, Scrimshaw, Sean Comber, Sumpter, Yen   +43 more
core   +1 more source

Effects of Propranolol, a β-noradrenergic Antagonist, on Memory Consolidation and Reconsolidation in Mice

Frontiers in Behavioral Neuroscience, 2016
Memory reconsolidation impairment using the β-noradrenergic receptor blocker propranolol is a promising novel treatment avenue for patients suffering from pathogenic memories, such as post-traumatic stress disorder (PTSD).
Hélène Villain, Aïcha Benkahoul, A. Drougard, Marie Lafragette, E. Muzotte, Stéphane Pech, E. Bui, A. Brunet, P. Birmes, P. Roullet   +9 more
semanticscholar   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

The anti-cancer effect of Propranolol in K562 cell line: an in vitro study

Armaghane Danesh Bimonthly Journal, 2016
Introduction: Β-AR receptors are one of the proteins involved in cancer and stress. The therapeutic activity of β-blockers such as propranolol is attributed to the blockade of β1-adrenergic receptors (ARs).
S Bastani, M Mohamadzade, Y Pazhang
doaj  

Propranolol therapy for infantile hemangioma: our experience

Drug Design, Development and Therapy, 2017
Objective Hemangiomas are the most common benign vascular tumors of infancy. Although most infantile hemangiomas (IHs) have the ability to involute spontaneously after initial proliferation and resolve without consequence, intervention is required in a ...
Ling Zhang, H. Wu, Wei-En Yuan, Jia-wei Zheng   +3 more
semanticscholar   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

The use of non-selective beta-blockers in patients with cirrhosis: more doubts than certainties [PDF]

, 2017
In conclusion, prospective RCT would be needed on the use of NSBBs in decompensated cirrhotic patients with ascites however these trials are difficult to organize and will need a large sample size.
Di Gregorio, Vincenza, D’Ambrosio, Daria, Lattanzi, Barbara, Merli, Manuela   +3 more
core   +1 more source

Novel 4,5‐Dihydrothiazole‐phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

ChemMedChem, Accepted Article.
We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi, Natalia Karkoszka, Rosa Sparaco, Angela Corvino, Beatrice Severino, Vincenzo Santagada, Elisa Magli, Ewa Gibuła-Tarłowska, Jolanta H. Kotlińska, Kinga Gawel, Raffaele Capasso, Anna Lesniak, Nataliia Semenko, Agnieszka A. Kaczor, Anna Bielenica, Grażyna Biała, Giuseppe Caliendo, Ewa Kędzierska, Ferdinando Fiorino   +18 more
wiley   +1 more source

The Costs of Changing Our Minds [PDF]

, 2014
This isn’t quite a draft yet – it’s a concept paper. You’ll see after the first 10 pages a good bit of text in brackets, which are primarily notes for me, but it’ll give you a sense of the content of those sections. I’d like to talk through the concept –
Farahany, Nita A.
core   +1 more source