Results 211 to 220 of about 25,303 (250)
Some of the next articles are maybe not open access.
Proprotein Convertases in Gynecological Cancers
Colloquium Series on Protein Activation and Cancer, 2012ABSTRACT Gynecological cancers include neoplasias of internal female genital organs, mainly ovarian, endometrial and cervical tumors, and cancers of the external female genital structures. Current scientific evidence indicates that both up- and down-regulation of the expression of PCs are part of the multiple changes occurring in these gynecological ...
Andres J.P. Klein-Szanto +2 more
openaire +1 more source
Proprotein convertase activation of aggrecanases in cartilage in situ
Archives of Biochemistry and Biophysics, 2008Proteolytic degradation of the major cartilage macromolecules, aggrecan and type II collagen, is a key pathological event in osteoarthritis (OA). ADAMTS-4 and ADAMTS-5, the primary aggrecanases capable of cartilage aggrecan cleavage, are synthesized as latent enzymes and require prodomain removal for activity.
Anne-Marie, Malfait +8 more
openaire +2 more sources
The Proprotein Convertases, 20 Years Later
2011The proprotein convertases (PCs) are secretory mammalian serine proteinases related to bacterial subtilisin-like enzymes. The family of PCs comprises nine members, PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9 (Fig. 3.1). While the first seven PCs cleave after single or paired basic residues, the last two cleave at non-basic residues ...
openaire +2 more sources
Tissue distribution and processing of proSAAS by proprotein convertases
Journal of Neurochemistry, 2001The conversion of inactive precursor proteins into bioactive neuropeptides and peptide hormones involves regulated secretory proteins such as prohormone convertases PC1 and PC2. The neuroendocrine protein 7B2 represents a specific binding protein for PC2, and the protein proSAAS, which interacts with PC1, exhibits certain structural and functional ...
M, Sayah +3 more
openaire +2 more sources
The proprotein convertases in health and disease
Qatar Foundation Annual Research Forum Volume 2012 Issue 1, 2012Background: The mammalian proprotein convertases (PCs) constitute a family of nine secretory serine proteases related to bacterial subtilisin and yeast kexin. Seven of them (PC1/3, PC2, furin, PC4, PC5/6, PACE4 and PC7) activate cellular and pathogen precursor proteins by cleavage at single or paired basic residues, while SKI-1/S1P and PCSK9 regulate ...
openaire +1 more source
Curbing activation: proprotein convertases in homeostasis and pathology
The FASEB Journal, 2003ABSTRACT The proprotein convertases (PCs) are a seven‐member family of endoproteases that activate proproteins by cleavage at basic motifs. Expression patterns for individual PCs vary widely, and all cells express several members. The list of substrates activated by PCs has grown to include neuropeptides, peptide hormones, growth and ...
Neil A, Taylor +2 more
openaire +2 more sources
The role of proprotein convertases in cancer
2013Le cancer est à l'origine d'environ 20% des décès dans le monde occidental. En 2008, près de 12,7 millions de nouveaux cas et 7,6 millions de décès sont survenus dans le monde. Le développement du cancer est un processus multi-étapes, au cours duquel les cellules acquièrent des mutations qui mènent à une croissance cellulaire incontrôlée, l'échappement
openaire +1 more source
Mouse Models of Human Proprotein Convertase Insufficiency
Endocrine Reviews, 2021Iris Lindberg
exaly