Results 51 to 60 of about 38,575 (293)
Coming Back to Physiology: Extra Hepatic Functions of Proprotein Convertase Subtilisin/Kexin Type 9
Frontiers in Physiology, 2020 Neuronal apoptosis regulated convertase-1 (NARC-1), now mostly known as proprotein convertase subtilisin/kexin type 9 (PCSK9), has received a lot of attention due to the fact that it is a key regulator of the low-density lipoprotein (LDL) receptor (LDL-R)
K. Schlüter +2 more
semanticscholar +1 more source
Inhibitory Feature of the Proprotein Convertases Prosegments
Medicinal Chemistry, 2008 The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors.
Bontemps, Yannick +4 more
openaire +5 more sources
Molecular Implications of natriuretic peptides in the protection from hypertension and target organ damage development [PDF]
, 2019 The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage.
Forte, Maurizio +3 more
core +1 more source
European Heart Journal - Quality of Care and Clinical Outcomes, 2020 Aims To assess the cost-effectiveness of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab added to standard-of-care lipid-lowering treatment [maximum tolerated dose (MTD) of statin and ezetimibe] in Swedish patients with a history
U. Landmesser +9 more
semanticscholar +1 more source
Sex-specific predictors of PCSK9 levels in a European population:The IMPROVE study [PDF]
, 2020 Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators of low density lipoprotein cholesterol plasma levels.
core +6 more sources
PCSK9 Biology and Its Role in Atherothrombosis [PDF]
, 2021 It is now about 20 years since the first case of a gain-of-function mutation involving the as-yet-unknown actor in cholesterol homeostasis, proprotein convertase subtilisin/kexin type 9 (PCSK9), was described.
Barale, Cristina +3 more
core +1 more source
PCSK9: From discovery to therapeutic applications [PDF]
, 2014 SummaryThe proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism mainly by targeting the low-density lipoprotein receptor (LDLR) for degradation in the liver.
Farnier, Michel
core +1 more source
Small molecule proprotein convertase inhibitors for inhibition of embryo implantation. [PDF]
PLoS ONE, 2013 Uterine proprotein convertase (PC) 6 plays a critical role in embryo implantation and is pivotal for pregnancy establishment. Inhibition of PC6 may provide a novel approach for the development of non-hormonal and female-controlled contraceptives.
Huiting Ho +8 more
doaj +1 more source
Studies on PCSK9 in the regulation of cholesterol metabolism [PDF]
, 2011 Elevated levels of plasma cholesterol, mainly in low density lipoproteins (LDL), are a major risk factor for coronary heart disease. The level of plasma LDL cholesterol (LDL-C) is largely dependent on the number of hepatic LDL receptors (LDLRs ...
Persson, Lena
core +1 more source
Hepatic Proprotein Convertases Modulate HDL Metabolism [PDF]
Cell Metabolism, 2007 The risk of atherosclerosis is inversely associated with plasma levels of high-density lipoprotein cholesterol (HDL-C). However, HDL metabolism is incompletely understood, and there are few effective approaches to modulate HDL-C levels. Here we show that inhibition in the liver of the classical proprotein convertases (PCs), but not the atypical PCs S1P
Daniel J. Rader +6 more
openaire +3 more sources