Results 51 to 60 of about 18,081 (213)
Frontiers in Immunology, 2021 Proprotein convertases (PC) are a family of 9 serine proteases involved in the processing of cellular pro-proteins. They trigger the activation, inactivation or functional changes of many hormones, neuropeptides, growth factors and receptors.
Mélanie Rose +3 more
doaj +1 more source
Gene editing therapy ready for cardiovascular diseases: opportunities, challenges, and perspectives
Medical Review, 2021 Gene editing nucleases (GENs), represented by CRISPR/Cas9, have become major tools in biomedical research and offer potential cures for many human diseases.
Zhou Jun +4 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract Current literature on the metabolic effects of long‐distance hiking is limited to case studies with discrepant findings, and no prior studies have examined the role of diet in shaping these outcomes. In this study, we investigated changes in lipid profiles and dietary factors among 12 participants who completed the Colorado Trail.
Kiaya Johnston +3 more
wiley +1 more source
Inhibitory Feature of the Proprotein Convertases Prosegments
Medicinal Chemistry, 2008 The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors.
Bontemps, Yannick +4 more
openaire +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland +4 more
wiley +1 more source
Polyphenols with indirect proprotein convertase inhibitory activity
International Journal of Oncology, 2013 Polyphenols, a class of natural products, have been shown to exhibit cancer protective properties. Proprotein convertases form a family of mammalian subtilisin-like serine endoproteases. Increased expression of these enzymes has been associated with numerous pathologies including cancer.
Jingjing, Zhu +2 more
openaire +3 more sources
RNA‐Based Therapies for Inherited Metabolic Disorders
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri +5 more
wiley +1 more source
Transforming hypercholesterolemia management: Spotlight on PCSK9 peptide vaccines
Cell Reports MedicineProprotein convertase subtilisin/kexin type 9 (PCSK9) is a therapeutic target for dyslipidemia and atherosclerotic cardiovascular disease (ASCVD). Two recent studies published by Fang et al.1 and Zhang et al.2 in Cell Reports Medicine and Cell Reports ...
Amirhossein Sahebkar, Maciej Banach
doaj +1 more source
Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome [PDF]
Diabetes & Metabolism Journal, 2018 BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor.
Kwi-Hyun Bae +11 more
doaj +1 more source
Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight patients with liver cirrhosis [PDF]
, 2021 Susanne Feder +7 more
openalex +1 more source