Results 31 to 40 of about 25,303 (250)

Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages [PDF]

, 2016
We demonstrated here thanks to proteomic, that proprotein convertase 1/3 knockdown macrophages present all the characteristic of activated pro-inflammatory macrophages.
Fournier, Isabelle, Adriana Murgoci, Duhamel, Marie, Salzet, Michel, Robert Day, Day, Robert, Isabelle Fournier, Wisztorski, Maxence, Marie Duhamel, Rodet, Franck, Maxence Wisztorski, Michel Salzet, Murgoci, Adriana, Franck Rodet   +13 more
core   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Molecular Consequences of Proprotein Convertase 1/3 (PC1/3) Inhibition in Macrophages for Application to Cancer Immunotherapy: A Proteomic Study [PDF]

, 2015
International audienceMacrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells.
Fournier, Isabelle, SALZET, Michel, Gagnon, Hugo, Gagnon, H., Salzet, M., Duhamel, Marie, Desjardins, Roxane, Kobeissy, F., Nataf, Serge, Day, R., Wisztorski, M., Duhamel, M., Desjardins, R., Day, Robert, Fournier, I., Delhem, Nadira, Delhem, N., Wisztorski, Maxence, Kobeissy, Firas H., Rodet, Franck, Vanden Abeele, F., Pays, Laurent, Vanden-Abeele, Fabien, Rodet, F.   +23 more
core   +1 more source

Small molecule proprotein convertase inhibitors for inhibition of embryo implantation. [PDF]

PLoS ONE, 2013
Uterine proprotein convertase (PC) 6 plays a critical role in embryo implantation and is pivotal for pregnancy establishment. Inhibition of PC6 may provide a novel approach for the development of non-hormonal and female-controlled contraceptives.
Huiting Ho, Harmeet Singh, Sophea Heng, Tracy L Nero, Sarah Paule, Michael W Parker, Alan T Johnson, Guan-Sheng Jiao, Guiying Nie   +8 more
doaj   +1 more source

Proprotein Convertase Subtilisin/Kexin Type 9 and Inflammation: An Updated Review

Frontiers in Cardiovascular Medicine, 2022
The function of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9), a novel plasma protein, has mainly been involved in cholesterol metabolism in the liver, while, more interestingly, recent data have shown that PCSK9 also took part in the modulation ...
Na-Qiong Wu, Hui-Wei Shi, Jian-Jun Li
doaj   +1 more source

Lipid-lowering interventions targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): an emerging chapter in lipid-lowering therapy

, 2017
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is mainly expressed in the liver but can also be found in the intestine and kidneys.
Constantine E Kosmas, Eddy DeJesus, Eliscer Guzman, Rosmery Morcelo, Peter D Montan, Frank Garcia   +5 more
core   +1 more source

Functional Regulation of Semaphorin Receptors by Proprotein Convertases [PDF]

Journal of Biological Chemistry, 2003
PLEXIN genes encode receptors for secreted and membrane-bound semaphorins. It was proposed that the extracellular domain of plexins acts as an inhibitory moiety, preventing receptor activation. Here we show that plexin-B1 and plexin-B2 undergo proteolytic processing in their extracellular portion, thereby converting single-chain precursors into non ...
ARTIGIANI, Stefania, BARBERIS D, FAZZARI, PIETRO, LONGATI P, ANGELINI P, VAN DE LOO JW, COMOGLIO, Paolo, TAMAGNONE, Luca   +7 more
openaire   +5 more sources

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease [PDF]

, 2022
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and
Odeberg, Jacob,, Lengquist, Mariette, Bergman, Otto,, Suur, Bianca E., Hurt-Camejo, Eva,, Eriksson, Per, Karlöf, Eva, Nyberg, Michael,, Ketelhuth, Daniel F.J., Bergman, Otto, Suur, Bianca E, Suur, Bianca E.,, Ketelhuth, Daniel F J, Nyberg, Michael, Chemaly, Melody, Lengquist, Mariette,, Stenemo, Markus, Chemaly, Melody,, Liljeqvist, Moritz Lindquist,, Ketelhuth, Daniel F. J.,, Stenemo, Markus,, Karlof, Eva,, Lindquist Liljeqvist, Moritz, Djordjevic, Djordje,, Eriksson, Per,, Hedin, Ulf,, Hurt-Camejo, Eva, Roy, Joy, Hedin, Ulf, Roy, Joy,, Matic, Ljubica,, Djordjevic, Djordje, Matic, Ljubica, Odeberg, Jacob   +33 more
core   +1 more source

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Inhibitory Feature of the Proprotein Convertases Prosegments

Medicinal Chemistry, 2008
The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors.
Bontemps, Yannick, Lapierre, Marion, Siegfried, Geraldine, Calvo, Fabien, Khatib, Abdel-Majid   +4 more
openaire   +3 more sources