Results 21 to 30 of about 25,303 (250)

Insight into the Evolving Role of PCSK9

Metabolites, 2022
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells.
Mateusz Maligłówka, Michał Kosowski, Marcin Hachuła, Marcin Cyrnek, Łukasz Bułdak, Marcin Basiak, Aleksandra Bołdys, Grzegorz Machnik, Rafał Jakub Bułdak, Bogusław Okopień   +9 more
doaj   +1 more source

PCSK4 (proprotein convertase subtilisin/kexin type 4) [PDF]

, 2015
Review on PCSK4 (proprotein convertase subtilisin/kexin type 4), with data on DNA, on the protein encoded, and where the gene is ...
Demoures, B, Khatib, M
core   +1 more source

Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells. [PDF]

World J Hepatol
BACKGROUND Proprotein convertase subtilisin/kexin type 9 (PCSK9) is abundantly expressed by hepatocytes and regulates the uptake of low-density lipoprotein by these parenchymal cells.
Bundschuh J, Neumann M, Zimny S, Spirk M, Buechler C.   +4 more
europepmc   +2 more sources

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9 [PDF]

Pharmacological Reviews, 2017
The secretory proprotein convertase (PC) family comprises nine members, as follows: PC1/3, PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin kexin isozyme 1/site 1 protease (SKI-1/S1P), and PC subtilisin/kexin type 9 (PCSK9).
Nabil G, Seidah, Marianne, Abifadel, Stefan, Prost, Catherine, Boileau, Annik, Prat   +4 more
openaire   +2 more sources

PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5) [PDF]

, 2015
Review on PCSK5 (Proprotein Convertase Subtilisin/Kexin Type 5), with data on DNA, on the protein encoded, and where the gene is ...
Demoures, B, Khatib, M
core   +1 more source

Characterization of granule-like structures in non-endocrine cells [PDF]

, 2006
All eukaryotic cells have transport pathways to constitutively secrete proteins. Endocrine, neuroendocrine, and exocrine cells in addition have a regulated secretory pathway that serves the controlled release of hormones, neuropeptides or digestive ...
Stettler, Hansruedi
core   +1 more source

Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia:Results of a 24week, double-blind, randomized Phase 3 trial [PDF]

, 2014
Background:Efficacy and safety of alirocumab were compared with ezetimibe in hypercholesterolemic patients at moderate cardiovascular risk not receiving statins or other lipid-lowering therapy. Methods In a Phase 3, randomized, double-blind, double-dummy
Merlet, Laurence, Robinson, Jennifer G., Kastelein, John J.P., Roth, Eli M., Colhoun, Helen M., Pordy, Robert, Taskinen, Marja-Riitta, Ginsberg, Henry N., Kastelein, John J. P., Baccara-Dinet, Marie T.   +9 more
core   +1 more source

Use of PCSK9 Inhibitors in Solid Organ Transplantation Recipients

JACC: Case Reports, 2020
Standard lipid-lowering therapies in solid organ transplantations pose challenges due to interactions with immunosuppressants. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid-lowering therapies with ...
Bruce A. Warden, PharmD, Tina Kaufman, PhD, PA-C, Jessica Minnier, PhD, P. Barton Duell, MD, Sergio Fazio, MD, PhD, Michael D. Shapiro, DO, MCR   +5 more
doaj   +1 more source

A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C. [PDF]

PLoS ONE, 2009
Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis.
Ajoy Basak, Abdel-Majid Khatib, Dayani Mohottalage, Sarmistha Basak, Maria Kolajova, Subhendu Sekhar Bag, Amit Basak   +6 more
doaj   +1 more source

Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation [PDF]

, 2015
Tissue patterning is established by extracellular growth factors or morphogens. Although different theoretical models explaining specific patterns have been proposed, our understanding of tissue pattern establishment invivo remains limited.
Evers-van Gogh, Inkie, Tessadori, Federico, Tessadon, F., Merks, R.M.H., Tessadori, F., Rens, Elisabeth G, Rens, Lisanne, Noël, Emily S., Merks, Roeland M. H., Evers-Van Gogh, I.J.A., Merks, Roeland M.H., Guardavaccaro, Daniele, Bakkers, J., Merks, Roeland M H, Merks, Roeland, Rens, E.G. (Lisanne), Evers-van Gogh, Inkie J. A., Rens, Elisabeth G., Merks, R.M.H. (Roeland), Evers-van Gogh, Inkie J.A., Noël, E.S., Noël, Emily S, Evers-van Gogh, Inkie J A, Bakkers, Jeroen, Rens, E.G., Magliozzi, R., Magliozzi, Roberto, Guardavaccaro, D.   +27 more
core   +2 more sources