Results 51 to 60 of about 25,303 (250)

The proprotein convertase furin is required for trophoblast syncytialization [PDF]

Cell Death & Disease, 2013
The multinucleated syncytial trophoblast, which forms the outermost layer of the placenta and serves multiple functions, is differentiated from and maintained by cytotrophoblast cell fusion. Deficiencies in syncytial trophoblast differentiation or maintenance likely contribute to intrauterine growth restriction and pre-eclampsia, two common gestational
Zhou, Z, Zhang, Q, Lu, X, Wang, R, Wang, H, Wang, Y-L, Zhu, C, Lin, H-Y, Wang, H   +8 more
openaire   +2 more sources

Long-term exposure to air pollution raises circulating levels of proprotein convertase subtilisin/kexin type 9 in obese individuals

, 2019
Aims Exposure to airborne particulate matter has been consistently associated with early death and increased morbidity, particularly raising the risk of cardiovascular disease.
Lupo, Maria G, Macchi, Chiara, Favero, Chiara, Pesatori, Angela C, Ferri, Nicola, Vigna, Luisella, Sirtori, Cesare R, Corsini, Alberto, Ruscica, Massimiliano, Bollati, Valentina, Cantone, Laura   +10 more
core   +1 more source

A new case of pcsk1 pathogenic variant with congenital proprotein convertase 1/3 deficiency and literature review [PDF]

, 2019
Issue: To report a homozygous pathogenic variant in PCSK1 in a boy affected with proprotein convertase 1/3 (PC1/3) deficiency. Case description and literature review: A male infant born to consanguineous Turkish parents presented in the first week of ...
E. Colin, Colin, Estelle, Coutant, Régis, Tessarech, Marine, Rouleau, Stéphanie, N. Bouhours-Nouet, D. Bonneau, S. Rouleau, Bonneau, Dominique, R. Coutant, Pépin, Lucie, L. Pépin, Bouhours-Nouet, Natacha, M. Tessarech   +13 more
core   +1 more source

Proprotein convertases: lessons from knockouts

The FASEB Journal, 2006
The physiological role of the subtilisin/kexin‐like proprotein convertases (PCs) in rodents has been examined through the use of knockout mice. This review will summarize the major in vivo defects that result from the disruption of the expression of their genes.
Nathalie, Scamuffa, Fabien, Calvo, Michel, Chrétien, Nabil G, Seidah, Abdel-Majid, Khatib   +4 more
openaire   +3 more sources

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

From lipoprotein apheresis to proprotein convertase subtilisin/kexin type 9 inhibitors: Impact on low-density lipoprotein cholesterol and C-reactive protein levels in cardiovascular disease patients [PDF]

, 2018
In this observational study, we compared the effect of lipoprotein apheresis and evolocumab or alirocumab on levels of lipoprotein cholesterol, triglycerides and inflammatory markers (C reactive protein and interleukin 6) in cardiovascular patients ( n =
Botta, Margherita, Lupo, Maria G, Bonora, Enzo, Zenti, Maria G, Ferri, Nicola, Corsini, Alberto, Ruscica, Massimiliano, Altomari, Anna   +7 more
core   +1 more source

P8 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 LEVELS AND ARTERIAL FUNCTION

Artery Research, 2017
Purpose/Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are modestly but significantly associated with increased risk of total cardiovascular events.
Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, John Skoumas, Nikitas Skliros, Magkas Nikolaos, Antigoni Miliou, Dimitrios Tousoulis   +7 more
doaj   +1 more source

Efficacy and Safety of Alirocumab as Add-on Therapy in High–Cardiovascular-Risk Patients With Hypercholesterolemia Not Adequately Controlled With Atorvastatin (20 or 40 mg) or Rosuvastatin (10 or 20 mg)::Design and Rationale of the ODYSSEY OPTIONS Studies [PDF]

, 2014
The phase 3 ODYSSEY OPTIONS studies (OPTIONS I, NCT01730040; OPTIONS II, NCT01730053) are multicenter, multinational, randomized, double-blind, active-comparator, 24-week studies evaluating the efficacy and safety of alirocumab, a fully human monoclonal ...
Peter H. Jones, Robinson, Jennifer G., Hanotin, Corinne, Du, Yunling, Jones, Peter H., Harold E. Bays, Corinne Hanotin, Yunling Du, Colhoun, Helen M., Donahue, Stephen, Jennifer G. Robinson, Helen M. Colhoun, Stephen Donahue, Bays, Harold E.   +13 more
core   +1 more source

Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease

, 2022
Proprotein convertase subtilisin/kexin 6 (PCSK6) is a secreted serine protease expressed in most major organs, where it cleaves a wide range of growth factors, signaling molecules, peptide hormones, proteolytic enzymes, and adhesion proteins.
Qingyu Wu, Shenghan Chen, Wu, Qingyu, Chen, Shenghan   +3 more
core   +1 more source

Cardiovascular and neuropsychiatric outcomes with PCSK9 inhibitors in atherosclerotic cardiovascular disease: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Study design and main findings. After 1:1 propensity score matching, 60 885 PCSK9 inhibitor users and 60 885 statin‐only users with ASCVD were compared. Kaplan–Meier curves show 12‐month cumulative event‐free survival for MACE, psychiatric disease, and neurodegenerative disease.
Tianshu Gu, Yang Chen, Nan Zhang, Uazman Alam, Riccardo Proietti, Tong Liu, Kang‐Yin Chen, Gregory Y. H. Lip   +7 more
wiley   +1 more source