Results 51 to 60 of about 313,411 (354)

PCSK9 Levels and Metabolic Profiles in Elderly Subjects with Different Glucose Tolerance under Statin Therapy [PDF]

, 2021
Proprotein convertase subtilisin/kexin type 9 (PCSK9) degrades low-density lipoprotein cholesterol (LDL-C) receptors, and thus regulates the LDL-C levels in the circulation. Type 2 diabetics often have elevated LDL-C levels.
Auvinen, Juha, Herzig, Karl-Heinz, Jokelainen, Jari, Järvelin, Marjo-Riitta, Keinänen-Kiukaanniemi, Sirkka, Leppäluoto, Juhani, Mäkelä, Kari A., Stenbäck, Ville, Tulppo, Mikko   +8 more
core   +1 more source

An Exploratory Analysis of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition and Aortic Stenosis in the FOURIER Trial.

JAMA cardiology, 2020
Importance Despite recent advances in treatment of severe aortic valve stenosis (AS), AS remains a life-threatening condition with no proven disease-modifying therapy.
B. Bergmark, M. O’Donoghue, S. Murphy, J. Kuder, M. Ezhov, R. Češka, I. Gouni-Berthold, H. Jensen, S. L. Tokgozoglu, F. Mach, K. Huber, Z. Gaciong, B. Lewis, F. Schiele, J. Jukema, T. Pedersen, R. Giugliano, M. Sabatine   +17 more
semanticscholar   +1 more source

Identification of Novel Proteins Interacting with Proprotein Convertase Subtilisin/Kexin 9

International Journal of Biomedical Investigation, 2020
High levels of cholesterol, especially as low-density lipoprotein (LDL), are a well-known risk factor for atherosclerotic-related diseases. The key atherogenic property of LDL is its ability to form atherosclerotic plaque. Proprotein convertase subtilisin/kexin-9 (PCSK9) is an indirect regulator of plasma LDL levels by controlling the number of LDL ...
Sreevidhya Krishnaji, David R. Kirchner, Kevin J. Knagge, Catherine J. Wooten, Dayami Lopez, Quantil M. Melendez   +5 more
openaire   +2 more sources

Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
Objective— Proprotein convertase subtilisin/kexin type 9 (PCSK9), which binds the low-density lipoprotein receptor and targets it for degradation, has emerged as an important regulator of serum cholesterol levels and cardiovascular disease risk.
Mary E. Haas, Praveen V. Manthena, Rosanne M. Crooke, Dong-Ju Shin, Ji Miao, Mark J. Graham, Sudha B. Biddinger, Jingwen Liu, Alisha V. Ling   +8 more
openaire   +3 more sources

Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9 [PDF]

The American Journal of Pathology, 2020
In a condition of dysfunctional visceral fat depots, as in the case of obesity, alterations in adipokine levels may be detrimental for the cardiovascular system. The proinflammatory leptin and resistin adipokines have been described as possible links between obesity and atherosclerosis.
Chiara Macchi, Maria Francesca Greco, Margherita Botta, Paola Sperandeo, Paola Dongiovanni, Luca Valenti, Arrigo F.G. Cicero, Claudio Borghi, Maria Giovanna Lupo, Stefano Romeo, Alberto Corsini, Paolo Magni, Nicola Ferri, Massimiliano Ruscica   +13 more
openaire   +3 more sources

Markers of neutrophil mediated inflammation associate with disturbed continuous electroencephalogram after out of hospital cardiac arrest

Acta Anaesthesiologica Scandinavica, Volume 67, Issue 1, Page 94-103, January 2023., 2023
Abstract Background Achieving an acceptable neurological outcome in cardiac arrest survivors remains challenging. Ischemia‐reperfusion injury induces inflammation, which may cause secondary neurological damage. We studied the association of ICU admission levels of inflammatory biomarkers with disturbed 48‐hour continuous electroencephalogram (cEEG ...
Pirkka T. Pekkarinen, Federico Carbone, Silvia Minetti, Davide Ramoni, Giuseppe Ristagno, Roberto Latini, Lauri Wihersaari, Kaj Blennow, Henrik Zetterberg, Jussi Toppila, Pekka Jakkula, Matti Reinikainen, Fabrizio Montecucco, Markus B. Skrifvars   +13 more
wiley   +1 more source

Effect of a novel nutraceutical combination on serum lipoprotein functional profile and circulating PCSK9 [PDF]

, 2017
BACKGROUND: A beneficial effect on cardiovascular risk may be obtained by improving lipid-related serum lipoprotein functions such as high-density lipoproteins (HDLs) cholesterol efflux capacity (CEC) and serum cholesterol loading capacity (CLC) and by ...
Adorni, Maria Pia, Bernini, Franco, Ferri, Nicola, Izzo, Raffaele, Marchiano, Silvia, Rozza, Francesco, Trimarco, Valentina, Zimetti, Francesca   +7 more
core   +3 more sources

Sex-specific predictors of PCSK9 levels in a European population:The IMPROVE study [PDF]

, 2020
Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators of low density lipoprotein cholesterol plasma levels.

core   +6 more sources

P8 PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 LEVELS AND ARTERIAL FUNCTION

Artery Research, 2017
Purpose/Background/Objectives: Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are modestly but significantly associated with increased risk of total cardiovascular events.
Losif Koutagiar, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, John Skoumas, Nikitas Skliros, Magkas Nikolaos, Antigoni Miliou, Dimitrios Tousoulis   +7 more
doaj   +1 more source

The Role of Spin(9) in Octonionic Geometry [PDF]

Axioms 2018, 7(4), 72, 2018
Starting from the 2001 Thomas Friedrich's work on Spin(9), we review some interactions between Spin(9) and geometries related to octonions. Several topics are discussed in this respect: explicit descriptions of the Spin(9) canonical 8-form and its analogies with quaternionic geometry as well as the role of Spin(9) both in the classical problems of ...
arxiv   +1 more source