Proprotein convertase subtilisin/kexin 9 inhibitors in reducing cardiovascular outcomes:A systematic review and meta-analysis [PDF]
, 2019 Background: To evaluate the effects of proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors on major adverse cardiovascular events (MACE).Methods: Our systematic review included randomised controlled trials if they studied PCSK9 inhibitors in ...
Du, Heyue +17 more
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Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition: The Big Step Forward in Lipid Control
European Cardiology Review, 2023 The breakthrough discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) 20 years ago revolutionised the current understanding of cholesterol homeostasis. Genetic studies have shown that gain-of-function mutations in PCSK9 lead to elevated LDL
Rishi Rikhi, Michael D Shapiro
doaj +1 more source
Levels of proprotein convertase subtilisin/kexin type 9 in patients with acute myocardial infarction
Российский кардиологический журнал, 2020 Aim. To study the levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with acute myocardial infarction (MI).Material and methods. The study included 74 patients with acute MI.
A. D. Gimadeeva +3 more
doaj +1 more source
SKI-1 and Furin Generate Multiple RGMa Fragments that Regulate Axonal Growth [PDF]
, 2012 SummaryThe nervous system is enormously complex, yet the number of cues that control axonal growth is surprisingly meager. Posttranslational modifications amplify diversity, but the degree to which they are employed is unclear.
Bermejo, Francisco Javier +8 more
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ESC Heart Failure, Volume 12, Issue 2, Page 859-868, April 2025.Abstract Aims Natriuretic peptide‐based pre‐heart failure screening has been proposed in recent guidelines. However, an effective strategy to identify screening targets from the general population, more than half of which are at risk for heart failure or pre‐heart failure, has not been well established.
Yuichiro Mori +5 more
wiley +1 more source
Circulating PCSK9 levels and CETP plasma activity are independently associated in patients with metabolic diseases [PDF]
, 2016 Additional file 1: Figure S1. Correlations between CETP activity and CETP mass (A) and between PCSK9 and CETP mass (B) in patients with T2DM (n=30).
Daiana Ibarretxe +6 more
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Studies on PCSK9 in the regulation of cholesterol metabolism [PDF]
, 2011 Elevated levels of plasma cholesterol, mainly in low density lipoproteins (LDL), are a major risk factor for coronary heart disease. The level of plasma LDL cholesterol (LDL-C) is largely dependent on the number of hepatic LDL receptors (LDLRs ...
Persson, Lena
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Research Models for Studying Vascular Calcification [PDF]
, 2020 Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen +4 more
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Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea
JPGN Reports, EarlyView.Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno +7 more
wiley +1 more source
Natriuretic Peptides in the Cardiovascular System. Multifaceted Roles in Physiology, Pathology and Therapeutics [PDF]
, 2019 The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological ...
Rubattu, Speranza, Volpe, Massimo
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