Results 71 to 80 of about 5,923 (228)
Proteina konbertasen adierazpena minbizi-zelula parental eta minbizi-zelula ametan (CSC) [PDF]
, 2017 [EUS] Minbizia hilkortasun oso handiko gaitza da, 2015. urtean 8,8 milioi hildako eragin zituen. Nahiz eta tratamendu bortitz eta luzeak aplikatu, askotan denbora baten ostean gaixotasunaren errekurrentzia gertatzen da, baita metastasiak ere.
Oiartzabal Narbarte, Irati
core
Suppressor of Cytokine Signaling-3 (SOCS-3) induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) expression in hepatic HepG2 cell line [PDF]
, 2015 The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor (TNF-\u3b1).
Corsini, Alberto +7 more
core +2 more sources
Functional Regulation of Semaphorin Receptors by Proprotein Convertases [PDF]
Journal of Biological Chemistry, 2003 PLEXIN genes encode receptors for secreted and membrane-bound semaphorins. It was proposed that the extracellular domain of plexins acts as an inhibitory moiety, preventing receptor activation. Here we show that plexin-B1 and plexin-B2 undergo proteolytic processing in their extracellular portion, thereby converting single-chain precursors into non ...
ARTIGIANI, Stefania +7 more
openaire +4 more sources
iNew Medicine, EarlyView.ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
Journal of Lipid Research, 2015 Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein,
Anna Roubtsova +7 more
doaj +1 more source
The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH. [PDF]
PLoS Genetics, 2010 Peptide hormones are potent signaling molecules that coordinate animal physiology, behavior, and development. A key step in activation of these peptide signals is their proteolytic processing from propeptide precursors by a family of proteases, the ...
Jeanne M Rhea +2 more
doaj +1 more source
An Overview of the Role of Furin in Type 2 Diabetes
Cells, 2023 Post-translational modifications (PTMs) play important roles in regulating several human diseases, like cancer, neurodegenerative disorders, and metabolic disorders. Investigating PTMs’ contribution to protein functions is critical for modern biology and
Sulaiman K. Marafie, Fahd Al-Mulla
doaj +1 more source
Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis [PDF]
, 2014 BACKGROUND: To investigate the mechanisms of lung adenocarcinoma cell metastasis and provide a theoretical basis for the in-depth study of lung adenocarcinoma.
Li Gao +5 more
core +2 more sources
Vascular Calcification: Mechanisms, Models, and Therapies
iNew Medicine, EarlyView.ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu +5 more
wiley +1 more source
Cells, 2019 During tumorigenesis, macrophages are recruited by tumors and orientated towards a pro-tumoral phenotype. One of the main anti-tumoral immunotherapy consists of their re-polarization in an anti-tumoral phenotype.
Franck Rodet +7 more
doaj +1 more source