Results 71 to 80 of about 8,088 (248)

Proteina konbertasen adierazpena minbizi-zelula parental eta minbizi-zelula ametan (CSC) [PDF]

, 2017
[EUS] Minbizia hilkortasun oso handiko gaitza da, 2015. urtean 8,8 milioi hildako eragin zituen. Nahiz eta tratamendu bortitz eta luzeak aplikatu, askotan denbora baten ostean gaixotasunaren errekurrentzia gertatzen da, baita metastasiak ere.
Oiartzabal Narbarte, Irati
core  

Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis [PDF]

, 2014
BACKGROUND: To investigate the mechanisms of lung adenocarcinoma cell metastasis and provide a theoretical basis for the in-depth study of lung adenocarcinoma.
Li Gao, Shu-Mei Rao, Song-Tao Xu, Wen-Juan Fan, Yong-Chao Ma, Zhan-Yu Bei   +5 more
core   +2 more sources

An Overview of the Role of Furin in Type 2 Diabetes

Cells, 2023
Post-translational modifications (PTMs) play important roles in regulating several human diseases, like cancer, neurodegenerative disorders, and metabolic disorders. Investigating PTMs’ contribution to protein functions is critical for modern biology and
Sulaiman K. Marafie, Fahd Al-Mulla
doaj   +1 more source

Functional Regulation of Semaphorin Receptors by Proprotein Convertases [PDF]

Journal of Biological Chemistry, 2003
PLEXIN genes encode receptors for secreted and membrane-bound semaphorins. It was proposed that the extracellular domain of plexins acts as an inhibitory moiety, preventing receptor activation. Here we show that plexin-B1 and plexin-B2 undergo proteolytic processing in their extracellular portion, thereby converting single-chain precursors into non ...
ARTIGIANI, Stefania, BARBERIS D, FAZZARI, PIETRO, LONGATI P, ANGELINI P, VAN DE LOO JW, COMOGLIO, Paolo, TAMAGNONE, Luca   +7 more
openaire   +4 more sources

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Suppressor of Cytokine Signaling-3 (SOCS-3) induces Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) expression in hepatic HepG2 cell line [PDF]

, 2015
The suppressor of cytokine signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines, including the tumor necrosis factor (TNF-\u3b1).
Corsini, Alberto, Cristofani, Riccardo, Ferri, Nicola, Liu, Jingwen, Macchi, Chiara, Magni, Paolo, Ricci, Chiara, Ruscica, Massimiliano   +7 more
core   +2 more sources

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S]

Journal of Lipid Research, 2015
Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein,
Anna Roubtsova, Ann Chamberland, Jadwiga Marcinkiewicz, Rachid Essalmani, Ali Fazel, John J. Bergeron, Nabil G. Seidah, Annik Prat   +7 more
doaj   +1 more source

PC1/3 KD Macrophages Exhibit Resistance to the Inhibitory Effect of IL-10 and a Higher TLR4 Activation Rate, Leading to an Anti-Tumoral Phenotype

Cells, 2019
During tumorigenesis, macrophages are recruited by tumors and orientated towards a pro-tumoral phenotype. One of the main anti-tumoral immunotherapy consists of their re-polarization in an anti-tumoral phenotype.
Franck Rodet, Alice Capuz, Bilgehan-Aybike Ozcan, Rémy Le Beillan, Antonella Raffo-Romero, Firas Kobeissy, Marie Duhamel, Michel Salzet   +7 more
doaj   +1 more source

High levels of serum cholesterol increase the risk of developing vessel co‐opting tumors in colorectal cancer liver metastases

The FEBS Journal, EarlyView.
High serum cholesterol is linked to colorectal cancer liver metastases (CRCLM) subtypes with poor survival (replacement pattern). Levels of cholesterol under 4 mmol·L−1 correlated with better survival and a desmoplastic pattern subtype. Furthermore, in vivo PCSK9 inhibitor evolocumab, which lowers cholesterol, reduced liver metastases.
Amatzia Gantz, Audrey Kapelanski‐Lamoureux, Miran Rada, Lucyna Krzywon, Migmar Tsamchoe, Anastasia Tsatoumas, Stephanie K. Petrillo, Nabil G. Seidah, Anthoula Lazaris, Peter Metrakos   +9 more
wiley   +1 more source

Evaluation of genome-wide loci of iron metabolism in hereditary hemochromatosis identifies PCSK7 as a host risk factor of liver cirrhosis [PDF]

, 2016
Genome-wide association studies (GWAS) have revealed genetic determinants of iron metabolism, but correlation of these with clinical phenotypes is pending.
Aigner, Elmar, Arlt, Alexander, Becker, Thomas, Berg, Thomas, Boehm, Bernhard O., Braun, Felix, Buch, Stephan, D'Amato, Mauro, Datz, Christian, Dejaco, Christian, Erhart, Wiebke, Finkenstedt, Armin, Franke, Andre, Gallati, Sabina, Hampe, Jochen, Hinrichsen, Holger, Hultcrantz, Rolf, Kratzer, Wolfgang, Krawczak, Michael, Krones, Elisabeth, Lerch, Markus M., Mayerle, Julia, Nothnagel, Michael, Sahinbegovic, Enijad, Sarrazin, Christoph, Schafmayer, Clemens, Schaller, André, Sipos, Bence, Stadlmayr, Andreas, Stal, Per, Stickel, Felix, Strasser, Michael, Torkvist, Leif, Völzke, Henry, Zoller, Heinz, Zwerina, Jochen, Österreicher, Christoph   +36 more
core   +2 more sources