Results 71 to 80 of about 18,795 (277)

Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels’ Activation in Breast Cancer Cells [PDF]

, 2021
The intracellular calcium concentration ([Ca2+]i) modulation plays a key role in the regulation of cellular growth and survival in normal cells and failure of [Ca2+]i homeostasis is involved in tumor initiation and progression.
Badiola Echaburu, Iker, Cantonero, Carlos, Descarpentrie, Jean, Evrard, Serge, Khatib, Abdel-Majid, López, Jose J., Pernot, Simon, Rosado, Juan A., Siegfried, Geraldine, Smani, Tarik, Soulet, Fabienne   +10 more
core   +2 more sources

Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea. [PDF]

, 2021
Proprotein convertase 1/3 (PC1/3), encoded by the PCSK1 gene, is expressed in neuronal and (entero)endocrine cell types, where it cleaves and hence activates a number of protein precursors that play a key role in energy homeostasis.
Aerts, Laetitia, Creemers, John, Martín, Martín, Ramos-Molina, Bruno, Sainath, Nina, Terry, Nathalie, Torres, Clarivet   +6 more
core   +2 more sources

60 YEARS OF POMC: From the prohormone theory to pro-opiomelanocortin and to proprotein convertases (PCSK1 to PCSK9).

Journal of Molecular Endocrinology, 2016
Pro-opiomelanocortin (POMC), is a polyprotein expressed in the pituitary and the brain where it is proteolytically processed into peptide hormones and neuropeptides with distinct biological activities. It is the prototype of multipotent prohormones.
M. Chrétien, M. Mbikay
semanticscholar   +1 more source

Genotype‐driven NPC1L1 and PCSK9 inhibition and reduced risk of periodontitis

Journal of Clinical Periodontology, Volume 50, Issue 1, Page 114-120, January 2023., 2023
Abstract Aim Epidemiological and pre‐clinical studies suggest a chemoprotective role of lipid‐lowering agents in periodontitis. We tested the association of genetically proxied inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMGCR), Niemann‐Pick C1‐Like 1 (NPC1L1) and proprotein convertase subtilisin/kexin type 9 (PCSK9) with ...
Sebastian‐Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjörg Baurecht, Michael Nolde   +7 more
wiley   +1 more source

Systemic lupus erythematosus and cardiovascular disease

Journal of Internal Medicine, Volume 293, Issue 1, Page 48-62, January 2023., 2023
Abstract The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment and care, but cardiovascular disease (CVD) still remains an important clinical problem, since the risk of CVD in SLE is much higher than among controls.
Johan Frostegård
wiley   +1 more source

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and
Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlöf, Mariette Lengquist, Jacob Odeberg, Jacob Odeberg, Eva Hurt-Camejo, Eva Hurt-Camejo, Per Eriksson, Daniel F.J. Ketelhuth, Daniel F.J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic   +19 more
doaj   +1 more source

Genetic and molecular architecture of familial hypercholesterolemia

Journal of Internal Medicine, Volume 293, Issue 2, Page 144-165, February 2023., 2023
Abstract Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its important risk of premature atherosclerosis and cardiovascular disease, familial hypercholesterolemia (FH) is still largely underdiagnosed worldwide. It is one of the most frequently inherited diseases due to mutations, for autosomal dominant forms, in ...
Marianne Abifadel, Catherine Boileau
wiley   +1 more source

Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.

PLoS ONE, 2021
Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have
Najmeh Parvaz, Zahra Jalali
doaj   +2 more sources

Analysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFs [PDF]

, 2010
Background: As important regulators of developmental and adult processes in metazoans, Fibroblast Growth Factor (FGF) proteins are potent signaling molecules whose activities must be tightly regulated.
Stathopoulos, Angelike, Tulin, Sarah
core   +4 more sources

The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia

Journal of Internal Medicine, Volume 293, Issue 2, Page 228-245, February 2023., 2023
Abstract Background Patients with familial hypercholesterolemia (FH) display high levels of low‐density lipoprotein cholesterol (LDL‐c), endothelial dysfunction, and increased risk of premature atherosclerosis. We have previously shown that red blood cells (RBCs) from patients with type 2 diabetes induce endothelial dysfunction through increased ...
Ali Mahdi, Tigist Wodaje, Oskar Kövamees, John Tengbom, Allan Zhao, Tong Jiao, Marcus Henricsson, Jiangning Yang, Zhichao Zhou, Anni I. Nieminen, Malin Levin, Aida Collado, Jonas Brinck, John Pernow   +13 more
wiley   +1 more source