Results 51 to 60 of about 2,918 (98)

Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

Nature Communications
Receptor binding of TGF-β and related ligands such as Activin-A requires cleavage of a furin site in their dimeric precursor proteins. Melanoma cells cleave one Activin-A subunit independently of furin and related proprotein convertases, raising ...
Manon Bulliard, Katarina Pinjusic, Laura Iacobucci, Céline Schmuziger, Nadine Fournier, Daniel B. Constam   +5 more
doaj   +1 more source

Structural insights into proprotein convertase activation facilitate the engineering of highly specific furin inhibitors

Nature Communications
Proprotein convertases (PCs), including furin and PC1/3 among nine mammalian homologues, mediate the maturation of numerous secreted substrates by proteolytic cleavage.
Rupert Klaushofer, Konstantin Bloch, Luisa Susanna Eder, Simone Marzaro, Mario Schubert, Eva Böttcher-Friebertshäuser, Hans Brandstetter, Sven O. Dahms   +7 more
doaj   +1 more source

Proprotein convertases: Key players in inflammation-related malignancies and metastasis. [PDF]

Cancer Lett, 2020
Siegfried G, Descarpentrie J, Evrard S, Khatib AM.   +3 more
europepmc   +1 more source

Phylogenetic analysis of Amphioxus genes of the proprotein convertase family, including aPC6C, a marker of epithelial fusions during embryology

International Journal of Biological Sciences, 2006
The proprotein convertases (PCs) comprise a family of subtilisin-like endoproteases that activate precursor proteins (including, prohormones, growth factors, and adhesion molecules) during their transit through secretory pathways or at the cell surface ...
Stéphanie Bertrand, Alain Camasses, Mathilde Paris, Nicholas D. Holland, Hector Escriva
doaj  

Proapelin is processed extracellularly in a cell line-dependent manner with clear modulation by proprotein convertases. [PDF]

Amino Acids, 2019
Shin K, Landsman M, Pelletier S, Alamri BN, Anini Y, Rainey JK.   +5 more
europepmc   +1 more source

Specific and Selective Inhibitors of Proprotein Convertases Engineered by Transferring Serpin B8 Reactive-Site and Exosite Determinants of Reactivity to the Serpin α1PDX. [PDF]

Biochemistry, 2019
Izaguirre G, Arciniega M, Quezada AG.
europepmc   +1 more source

Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth. [PDF]

Mol Carcinog, 2017
Bassi DE, Zhang J, Renner C, Klein-Szanto AJ.   +3 more
europepmc   +1 more source

Proprotein convertases generate a highly functional heterodimeric form of thymic stromal lymphopoietin in humans. [PDF]

J Allergy Clin Immunol, 2017
Poposki JA, Klingler AI, Stevens WW, Peters AT, Hulse KE, Grammer LC, Schleimer RP, Welch KC, Smith SS, Sidle DM, Conley DB, Tan BK, Kern RC, Kato A.   +13 more
europepmc   +1 more source

Relative expression of proprotein convertases in rat ovaries during pregnancy. [PDF]

J Ovarian Res, 2013
Kwok SC, Chakraborty D, Soares MJ, Dai G.   +3 more
europepmc   +1 more source

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions. [PDF]

J Biol Chem, 2013
Seidah NG, Sadr MS, Chrétien M, Mbikay M.   +3 more
europepmc   +1 more source