Results 41 to 50 of about 2,918 (98)
The proprotein convertase encoded by amontillado (amon) is required in Drosophila corpora cardiaca endocrine cells producing the glucose regulatory hormone AKH. [PDF]
PLoS Genetics, 2010 Peptide hormones are potent signaling molecules that coordinate animal physiology, behavior, and development. A key step in activation of these peptide signals is their proteolytic processing from propeptide precursors by a family of proteases, the ...
Jeanne M Rhea +2 more
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An Overview of the Role of Furin in Type 2 Diabetes
Cells, 2023 Post-translational modifications (PTMs) play important roles in regulating several human diseases, like cancer, neurodegenerative disorders, and metabolic disorders. Investigating PTMs’ contribution to protein functions is critical for modern biology and
Sulaiman K. Marafie, Fahd Al-Mulla
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Cells, 2019 During tumorigenesis, macrophages are recruited by tumors and orientated towards a pro-tumoral phenotype. One of the main anti-tumoral immunotherapy consists of their re-polarization in an anti-tumoral phenotype.
Franck Rodet +7 more
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Biomolecular Concepts, 2011 There is increasing interest in the therapeutic targeting of proteases for the treatment of important diseases. Additionally new protein-based therapeutic strategies have the potential to widen the available treatments against these pathologies.
Couture Frédéric +2 more
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Urine peptidome analysis in cardiorenal syndrome reflects molecular processes
Scientific Reports, 2021 The cardiorenal syndrome (CRS) is defined as the confluence of heart-kidney dysfunction. This study investigates the molecular differences at the level of the urinary peptidome between CRS patients and controls and their association to disease ...
Eleni Petra +6 more
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FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
Scientific Reports, 2017 In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in
Edward R. Smith +3 more
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Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice
Cells, 2020 Proprotein convertases (PCSKs) process matrix metalloproteases and cytokines, but their function in the vasculature is largely unknown. Previously, we demonstrated upregulation of PCSK6 in atherosclerotic plaques from symptomatic patients, localization ...
Samuel Röhl +8 more
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Furin‐mediated protein processing in infectious diseases and cancer
Clinical & Translational Immunology, 2019 Proteolytic cleavage regulates numerous processes in health and disease. One key player is the ubiquitously expressed serine protease furin, which cleaves a plethora of proteins at polybasic recognition motifs.
Elisabeth Braun, Daniel Sauter
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Influence of organic solvents on the furin activity
The Ukrainian Biochemical Journal, 2018 Furin belongs to a family of calcium-dependent serine proprotein convertases, which transform the inactive protein precursors into mature polypeptides.
T. V. Osadchuk +3 more
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The Role of Proprotein Convertases in Upper Airway Remodeling. [PDF]
Mol Cells, 2022 Lee SN, Yoon JH.
europepmc +1 more source