Results 21 to 30 of about 2,918 (98)

Human spermatozoa anti-proprotein convertase subtilisin/kexin type 4 synthesis using New Zealand rabbit for novel immunocontraception in males [PDF]

Investigative and Clinical Urology, 2019
Purpose: Proprotein convertase subtilisin/kexin type 4 (PCSK4, a 54-kDa protease) is expressed in the plasma membrane of the acrosome in human spermatozoa. It plays a critical role in penetrating the zona pellucida. Synthesis of human anti-PCSK4 might be
Dahril, Aulanni'am, Vivi Keumala, Akhmad Mustafa   +3 more
doaj   +1 more source

Hepatic Proprotein Convertases Modulate HDL Metabolism [PDF]

Cell Metabolism, 2007
Thomas Quertermous, Daniel Rader, George H Rothblat   +2 more
exaly   +2 more sources

Characterization of the Proprotein Convertase-Mediated Processing of Peroxidasin and Peroxidasin-like Protein

Antioxidants, 2021
Peroxidasin (PXDN) and peroxidasin-like protein (PXDNL) are members of the peroxidase-cyclooxygenase superfamily. PXDN functions in basement membrane synthesis by forming collagen IV crosslinks, while the function of PXDNL remains practically unknown. In
Hajnal A. Kovács, Enikő Lázár, György Várady, Gábor Sirokmány, Miklós Geiszt   +4 more
doaj   +1 more source

SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2

Viruses, 2023
Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein (S)
Rachid Essalmani, Ursula Andréo, Alexandra Evagelidis, Maïlys Le Dévéhat, Oscar Henrique Pereira Ramos, Carole Fruchart Gaillard, Delia Susan-Resiga, Éric A. Cohen, Nabil G. Seidah   +8 more
doaj   +1 more source

Hysteretic behavior of proprotein convertase 1/3 (PC1/3). [PDF]

PLoS ONE, 2011
The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes.
Marcelo Y Icimoto, Nilana M Barros, Juliana C Ferreira, Marcelo F Marcondes, Douglas Andrade, Mauricio F Machado, Maria A Juliano, Wagner A Júdice, Luiz Juliano, Vitor Oliveira   +9 more
doaj   +1 more source

Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model. [PDF]

PLoS ONE, 2010
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted drug delivery would be desirable.
Katarina Hajdin, Valentina D'Alessandro, Felix K Niggli, Beat W Schäfer, Michele Bernasconi   +4 more
doaj   +1 more source

Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases

BMC Cancer, 2005
Background The family of proprotein convertases has been recently implicated in tumorigenesis and metastasis in animal models. However, these studies have not yet been completely corroborated in human tumors.
Marcus Victoria, Khatib Abdel M, Nguyên Duc, Jenna Sarah, Chevet Eric, Tzimas George N, Zhang Yi, Chrétien Michel, Seidah Nabil, Metrakos Peter   +9 more
doaj   +1 more source

Sphingomyelinases D From Loxosceles Spider Venoms and Cell Membranes: Action on Lipid Rafts and Activation of Endogenous Metalloproteinases

Frontiers in Pharmacology, 2020
Loxosceles spider venom contains Sphingomyelinase D (SMase D), the key toxin causing pathology. SMase D hydrolyzes the main component of lipid rafts, sphingomyelin, which changes the membrane microenvironment resulting in the activation of endogenous ...
Priscila Hess Lopes, Carmen W. van den Berg, Denise V. Tambourgi   +2 more
doaj   +1 more source

The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer

Journal of Lipid Research, 2021
In 2003, the sequences of mammalian proprotein convertase subtilisin/kexin type 9 (PCSK9) were reported. Radiolabeling pulse-chase analyses demonstrated that PCSK9 was synthesized as a precursor (proPCSK9) that undergoes autocatalytic cleavage in the ...
Nabil G. Seidah
doaj   +1 more source

The Dual α-Amidation System in Scorpion Venom Glands

Toxins, 2019
Many peptides in scorpion venoms are amidated at their C-termini. This post-translational modification is paramount for the correct biological function of ion channel toxins and antimicrobial peptides, among others.
Gustavo Delgado-Prudencio, Lourival D. Possani, Baltazar Becerril, Ernesto Ortiz   +3 more
doaj   +1 more source