Results 31 to 40 of about 2,918 (98)

The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

iScience, 2022
Summary: The generation of mature T cells and establishment of central tolerance is predominantly orchestrated by thymic epithelial cells (TECs). Proprotein convertases are responsible for the proteolysis of proproteins into their mature bioactive ...
Zhanfeng Liang, Zhaoqi Zhang, Qian Zhang, Xue Dong, Xiaofeng Yang, Jiayu Zhang, Tong Lei, John W.M. Creemers, Baojun Zhang, Yong Zhao   +9 more
doaj   +1 more source

Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

Neoplasia: An International Journal for Oncology Research, 2013
The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto   +7 more
doaj   +1 more source

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease

Frontiers in Pharmacology, 2022
Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and
Bianca E. Suur, Melody Chemaly, Moritz Lindquist Liljeqvist, Djordje Djordjevic, Djordje Djordjevic, Markus Stenemo, Otto Bergman, Eva Karlöf, Mariette Lengquist, Jacob Odeberg, Jacob Odeberg, Eva Hurt-Camejo, Eva Hurt-Camejo, Per Eriksson, Daniel F.J. Ketelhuth, Daniel F.J. Ketelhuth, Joy Roy, Ulf Hedin, Michael Nyberg, Ljubica Matic   +19 more
doaj   +1 more source

Molecular evolution of PCSK family: Analysis of natural selection rate and gene loss.

PLoS ONE, 2021
Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have
Najmeh Parvaz, Zahra Jalali
doaj   +2 more sources

Discovery of the Proprotein Convertases and their Inhibitors [PDF]

Regulation of Carcinogenesis, 2006
Nabil Seidah, Abdel-Majid Khatib, Michel Chretien   +2 more
exaly   +1 more source

Diversity in Proprotein Convertase Reactivity among Human Papillomavirus Types

Viruses, 2023
The cleavage of viral surface proteins by furin is associated with some viruses’ high virulence and infectivity. The human papillomavirus (HPV) requires the proteolytic processing of its capsid proteins for activation before entry.
Gonzalo Izaguirre, Lam Minh Uyen Phan, Shaan Asif, Samina Alam, Craig Meyers, Lijun Rong   +5 more
doaj   +1 more source

Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

Cell Reports, 2018
Summary: Furin trafficking, and that of related proprotein convertases (PCs), may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking.
Pierpaolo Ginefra, Bruno G.H. Filippi, Prudence Donovan, Sylvain Bessonnard, Daniel B. Constam   +4 more
doaj   +1 more source

How the Prohormone Theory Solved Two Important Controversies in Hormonal and Neural Peptide Biosynthesis

Frontiers in Endocrinology, 2013
This Prohormone Theory was simultaneously proposed in 1967 by two independent groups using two different approaches and two experimental models. Donald Steiner, in elegant pulse-chase experiments, proposed the existence of proinsulin when he observed ...
Michel eChretien
doaj   +1 more source

Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9

Journal of Lipid Research, 2021
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low density lipoprotein receptors (LDLRs). Plasma PCSK9 has 2 main molecular forms: a 62 kDa mature form (PCSK9_62) and a 55 kDa,
Carlota Oleaga, Joshua Hay, Emma Gurcan, Larry L. David, Paul A. Mueller, Hagai Tavori, Michael D. Shapiro, Nathalie Pamir, Sergio Fazio   +8 more
doaj   +1 more source

PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice[S]

Journal of Lipid Research, 2015
Proprotein convertase subtilisin kexin type 9 (PCSK9), the last member of the family of Proprotein Convertases related to Subtilisin and Kexin, regulates LDL-cholesterol by promoting the endosomal/lysosomal degradation of the LDL receptor (LDLR). Herein,
Anna Roubtsova, Ann Chamberland, Jadwiga Marcinkiewicz, Rachid Essalmani, Ali Fazel, John J. Bergeron, Nabil G. Seidah, Annik Prat   +7 more
doaj   +1 more source