Results 201 to 210 of about 5,989 (280)

Heart Rate Variability in Newborns From Diabetic Mothers: Clinical Application and Significance

open access: yesAnnals of Noninvasive Electrocardiology, Volume 31, Issue 3, May 2026.
Risk factors for GDM contribute to a hyperglycemic intrauterine environment, which may in turn impair ANS function in the offspring. Altered ANS activity can be assessed through measures such as HRV. ABSTRACT Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications, arising from inadequate insulin secretion and increased ...
Virginia Beretta   +7 more
wiley   +1 more source

Exploring ocular fundus morphology in relation to growth in adolescents born moderate‐to‐late preterm

open access: yesActa Ophthalmologica, Volume 104, Issue 3, Page e346-e355, May 2026.
Abstract Purpose To study ocular fundus morphology and its relation to growth in adolescents born moderate‐to‐late preterm (MLP) and full term. Methods This prospective and population‐based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full‐term controls (30 girls, mean age 16.7 years).
Alexandra Lind   +6 more
wiley   +1 more source

Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2518-2532, May 2026.
Background and Purpose Dopamine receptor agonists, particularly targeting the dopamine D2L receptor (D2LR), have been used to treat Parkinson's disease (PD). However, valvular heart disease and somnolence, mainly caused by activating the serotonin 5‐HT2B receptor (5‐HT2BR) and dopamine D3 receptor (D3R), respectively, currently challenge their clinical
Takayuki Suzuki   +4 more
wiley   +1 more source

The Effect of the Anticonvulsant Topiramate on Acetylcholine‐Induced Calcium Signals is Linked to Sirt‐1 Activity

open access: yesEuropean Journal of Neuroscience, Volume 63, Issue 9, May 2026.
This work provides a potential new link between the anticonvulsive Topiramate, the deacetylase Sirt‐1 and the cholinergic signalling, suggesting that Topiramate may modulate cholinergic pathways in a Sirt‐1 depended manner. ABSTRACT Although some forms of epilepsy directly result from mutations in nicotinic acetylcholine receptors, none of the ...
Marie‐Luise Kümmel
wiley   +1 more source

Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12‐week DTI study

open access: yesJournal of Child Psychology and Psychiatry, Volume 67, Issue 5, Page 696-706, May 2026.
Background Bipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention‐deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology ...
Kun Qin   +10 more
wiley   +1 more source

Urine‐Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome

open access: yesJournal of Neurochemistry, Volume 170, Issue 5, May 2026.
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Michele Martins   +9 more
wiley   +1 more source

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