Results 71 to 80 of about 71,694 (241)

Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers

Animal Research and One Health, EarlyView.
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng, Qi Zhang, Xinxin Tang, Fan Ying, Dawei Liu, Sen Li, Ranran Liu, Jie Wen, QingHe Li, Guiping Zhao   +9 more
wiley   +1 more source

Electric Field Driven Torque in ATP Synthase [PDF]

Miller, J.H., Jr., Rajapakshe, K.I., Infante, H.L. & Claycomb, J.R. Electric Field Driven Torque in ATP Synthase. PLoS ONE 8, e74978 (2013), 2013
Fo-ATP synthase (Fo) is a rotary motor that converts potential energy from ions, usually protons, moving from high- to low-potential sides of a membrane into torque and rotary motion. Here we propose a mechanism whereby electric fields emanating from the proton entry and exit channels act on asymmetric charge distributions in the c-ring, due to ...
arxiv   +1 more source

Cyclooxygenase-2, Not Microsomal Prostaglandin E Synthase-1, Is the Mechanism for Interleukin-1β-induced Prostaglandin E2 Production and Inhibition of Insulin Secretion in Pancreatic Islets*

Journal of Biological Chemistry, 2012
Background: The mechanism whereby IL-1β induces islet PGE2 production and inhibition of insulin secretion is unclear. Results: Basal COX-2 protein levels are stimulated by IL-1β; mPGES-1 levels are not.
S. Parazzoli, J. Harmon, Sara N. Vallerie, Tao Zhang, Huarong Zhou, R. P. Robertson   +5 more
semanticscholar   +1 more source

Sirt5 regulates chondrocyte metabolism and osteoarthritis development through protein lysine malonylation

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocyte metabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein post‐translational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK) and its regulator Sirt5 in OA development ...
Huanhuan Liu, Anupama Binoy, Siqi Ren, Thomas C. Martino, Anna E. Miller, Craig R. G. Willis, Shivakumar R. Veerabhadraiah, Joanna Bons, Jacob P. Rose, Birgit Schilling, Michael J. Jurynec, Shouan Zhu   +11 more
wiley   +1 more source

Fluorescent nanodiamonds for FRET-based monitoring of a single biological nanomotor FoF1-ATP synthase [PDF]

, 2009
Color centers in diamond nanocrystals are a new class of fluorescence markers that attract significant interest due to matchless brightness, photostability and biochemical inertness. Fluorescing diamond nanocrystals containing defects can be used as markers replacing conventional organic dye molecules, quantum dots or autofluorescent proteins. They can
arxiv   +1 more source

Lipopolysaccharide-Induced Expression of Microsomal Prostaglandin E Synthase-1 Mediates Late-Phase PGE2 Production in Bone Marrow Derived Macrophages

PLoS ONE, 2012
Cyclooxygenase (COX)-2 expression and release of prostaglandins (PGs) by macrophages are consistent features of lipopolysaccharide (LPS)-induced macrophage inflammation.
Lei Xiao, M. Ornatowska, Guiqing Zhao, H. Cao, Rui Yu, Jing Deng, Yongchao Li, Qiong Zhao, R. Sadikot, J. Christman   +9 more
semanticscholar   +1 more source

Human glutathione dependent prostaglandin E synthase: gene structure and regulation [PDF]

FEBS Letters, 2000
A P1 clone containing the gene for human glutathione dependent PGE synthase (PGES) was isolated and characterized. The gene is divided into three exons, spans 14.8 kb and was localized to chromosome 9q34.3. In A549 cells, the protein and activity levels of PGES were increased by interleukin‐1β. This increase was prevented by phenobarbital.
Ralf Morgenstern, Lena Forsberg, Lisa Leeb, Staffan Thorén, Per-Johan Jakobsson   +4 more
openaire   +3 more sources

The involvement of miR-6615-5p/Smad7 axis and immune imbalance in ammonia-caused inflammatory injury via NF-κB pathway in broiler kidneys

Poultry Science, 2020
Ammonia (NH3), a toxic gas, has deleterious effects on chicken health in intensive poultry houses. MicroRNA can mediate inflammation. The complex molecular mechanisms underlying NH3 inhalation–caused inflammation in animal kidneys are still unknown.
Qi Han, Jianyu Tong, Qi Sun, Xiaojie Teng, Hongfu Zhang, Xiaohua Teng   +5 more
doaj  

Monitoring transient elastic energy storage within the rotary motors of single FoF1-ATP synthase by DCO-ALEX FRET [PDF]

, 2012
The enzyme FoF1-ATP synthase provides the 'chemical energy currency' adenosine triphosphate (ATP) for living cells. Catalysis is driven by mechanochemical coupling of subunit rotation within the enzyme with conformational changes in the three ATP binding sites.
arxiv   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source