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Pathophysiological role of prostaglandin E synthases in liver diseases
Prostaglandins and Other Lipid Mediators, 2021Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) into prostaglandin E2 (PGE2) and comprise at least three types of structurally and biologically distinct enzymes. Two of these, namely microsomal prostaglandin E synthase-1 (mPGES-1) and mPGES-2, are membrane-bound enzymes.
Ying Sun
exaly +3 more sources
Expression of prostaglandin E synthases in the bovine oviduct
Theriogenology, 2010The oviduct is a specialized organ responsible for the storage and the transport of male and female gametes. It also provides an optimal environment for final gamete maturation, fertilization, and early embryo development. Prostaglandin (PG) E(2) is involved in many female reproductive functions, including ovulation, fertilization, implantation, and ...
M A Fortier
exaly +3 more sources
Sequential induction of prostaglandin E and D synthases in inflammation
Biochemical and Biophysical Research Communications, 2005Enhanced biosynthesis of prostaglandin (PG)D(2) and subsequent formation of 15-deoxy-Delta(12,14)-PGJ(2) has been suggested to contribute to resolution of inflammation. The primary aim of the present study in mouse heart was, therefore, to determine at the transcriptional level if there is sequential induction of PGE and PGD synthases (S) during ...
Magdalena Grill +2 more
exaly +3 more sources
Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami +3 more
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Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG)H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami +3 more
openaire +2 more sources
Prostaglandin E synthase in the pathophysiology of arthritis
Fundamental & Clinical Pharmacology, 2005AbstractProstaglandin E synthase (PGES) is a recently identified terminal enzyme that acts downstream of cyclooxygenase and catalyzes the conversion of prostaglandin (PG) H2 to PGE2. At least three isozymes have been cloned so far, which are called membrane‐associated PGES (mPGES)‐1, mPGES‐2, and cytosolic PGES.
Fumiaki, Kojima +2 more
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Biochemical and Biophysical Research Communications, 1997
Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg). In non-genital organs, the kidney had the highest activity (8 nmol/min x mg).
K, Watanabe +3 more
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Prostaglandin (PG) E synthase was found to be widely distributed in the microsomal fractions of rat organs. Among them, an extremely high activity was seen in the deferent duct (112 nmol/min x mg) and other genital accessory organs (10-20 nmol/min x mg). In non-genital organs, the kidney had the highest activity (8 nmol/min x mg).
K, Watanabe +3 more
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Expression of prostaglandin E synthase in Barrett’s cancer
Diseases of the Esophagus, 2008Expression of prostaglandin E synthase (PGES) - an enzyme of the prostaglandin biosynthetic pathway with suspected impact on carcinogenesis--was studied in Barrett's cancer to determine its pathogenetic role and prognostic impact in this entity. Expression analysis of PGES was performed on mRNA level (quantitative reverse transcription polymerase chain
B H A, von Rahden +6 more
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Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney
American Journal of Physiology-Renal Physiology, 2003PGE2, the major cyclooxygenase (COX) metabolite of arachidonic acid, is an important paracrine regulator of numerous tubular and vascular functions in the kidney. To date, COX activity has been considered the key step in prostaglandin synthesis and is well characterized.
Amanda L, Fuson +4 more
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Cyclooxygenases and prostaglandin E synthases in preimplantation mouse embryos
Zygote, 2005Prostaglandin E2 (PGE2) is shown to be essential for female reproduction. Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandin synthesis from arachidonic acid and exists in two isoforms: COX-1 and COX-2. Prostaglandin E synthase (PGES) is a terminal prostanoid synthase and can catalyse the isomerization of the COX product PGH2 to PGE2 ...
Tan, H. N. +3 more
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Characterization of Microsomal, Glutathione Dependent Prostaglandin E Synthase
2002Terminal prostanoid synthases constitute a group of several specific enzymes that catalyze the further metabolism of cyclooxygenase-derived prostaglandin H2. The efficient biosynthesis of prostaglandin E2 requires prostaglandin E synthase (E.C. 5.3.99.3). High prostaglandin E synthase (PGES) activity is found in the sheep and bovine vesicular gland. In
Per-Johan, Jakobsson +3 more
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