Results 71 to 80 of about 9,035 (267)

Changes in the expression of prostaglandin E and F synthases at induced and spontaneous labour onset in the sheep

, 2004
The differential production of prostaglandin (PG) F(2 alpha) and PGE(2) within the uterine compartment may play a role in controlling myometrial contraction. We hypothesized that the enzymes downstream of PG endoperoxide synthase-2 (PGHS-2) determine the
Rice, G., Hirst, J. J., Ooi, G. T., Dellios, N. L., Palliser, H. K., Escalona, R. M., Young, I. R.   +6 more
core   +1 more source

Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development

, 1999
Prostaglandin G and H synthases, or cyclooxygenases (COXs), catalyze the formation of prostaglandins (PGs). Whereas COX-1 is diffusely expressed in lymphoid cells in embryonic day 15.5 thymus, COX-2 expression is sparse, apparently limited to stromal ...
Ellen Puré, Robert Langenbach, Garret A. FitzGerald, Lisa M. Spain, Carlo Patrono, Patrono, Carlo, Bianca Rocca, Rocca, Bianca   +7 more
core   +1 more source

A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]

, 2013
: The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Leone, V, Yildiz, Ö, Meier, T, Iglesias-Cans, M, Cook, G., Sarah Schulz (426341), Meier, Thomas, Sarah Schulz, Matthies, D., Meier, T. ; https://orcid.org/, Schulz, Sarah, Özkan Yildiz (244574), M. Cook, Gregory, Doreen Matthies (426343), Thomas Meier, José D. Faraldo-Gómez (426344), Faraldo-Gómez, J., José D Faraldo-Gómez, Yildiz, Ö. ; https://orcid.org/, Iglesias-Cans, Marina, Gregory M. Cook (255231), Krah, A, Alexander Krah, https://orcid.org/, Vanessa Leone, Cook, Gregory M., Yildiz, Özkan, Meier, Thomas Kurt, Alexander Krah (217992), Cook, GM, Iglesias-Cans, M., Schulz, S, Doreen Matthies, Schulz, S., Leone, Vanessa, Matthies, D, Leone, V., Marina Iglesias-Cans, Marina Iglesias-Cans (426342), Thomas Meier (244580), Gregory M Cook, Krah, Alexander, Matthies, Doreen, Faraldo-Gómez, José D., Faraldo-Gómez, JD, Vanessa Leone (266195), Ozkan Yildiz, Krah, A.   +47 more
core   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Efectos renales de los inhibidores selectivos de la ciclooxigenasa-2 (COX-2) en la cirrosis. Estudios "in vivo" en ratas inducidas a cirrosis y estudios "in vitro" en células mesangiales. [PDF]

, 2006
[spa] En la cirrosis descompensada, la síntesis renal de prostaglandinas (PGs), juega un papel clave en el mantenimiento de la función renal. En concreto, las PGs renales contrarrestan la exacerbada actividad vasoconstrictora asociada a la activación de ...
López Parra, Marta
core  

Evolution of Conifer Diterpene Synthases: Diterpene Resin Acid Biosynthesis in Lodgepole Pine and Jack Pine Involves Monofunctional and Bifunctional Diterpene Synthases

, 2013
Diterpene resin acids (DRAs) are major components of pine (Pinus spp.) oleoresin. They play critical roles in conifer defense against insects and pathogens and as a renewable resource for industrial bioproducts.
Jancsik, Sharon, Madilao, Lina L., Dullat, Harpreet, Yuen, Macaire, Bohlmann, Jörg, Zerbe, Philipp, Quesada, Alfonso L., Hall, Dawn E.   +7 more
core   +1 more source

Phototriggering Nitric Oxide Synthase from Geobacillus stearothermophilus [PDF]

, 2012
Nitric oxide synthases (NOS) produce L-citrulline and nitric oxide (NO) in two turnovers from L-arginine via the bound intermediate, N-hydroxy-L-arginine.
Keller, Gretchen Eva, Gretchen Eva Keller   +1 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Microsomal prostaglandin E synthase-1 and blood pressure regulation [PDF]

Kidney International, 2007
Prostaglandin E (PGE)(2) is a major arachidonic acid metabolite in a wide variety of tissues and is implicated in the control of inflammatory as well as physiological responses. At least three major forms of PGE synthase (PGES) have recently been cloned and characterized: membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).
openaire   +2 more sources