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Biochemical and Biophysical Research Communications, 2021
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous immune responses was recently shown, the roles of these PG terminal synthases remain ...
Tsubasa, Ochiai +5 more
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Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) and prostacyclin (PGI2) synthase (PGIS) are PG terminal synthases that work downstream of cyclooxygenase and synthesize PGE2 and PGI2, respectively. Although the involvement of PG receptors in acquired cutaneous immune responses was recently shown, the roles of these PG terminal synthases remain ...
Tsubasa, Ochiai +5 more
openaire +2 more sources
Purification and characterization of recombinant microsomal prostaglandin E synthase-1
Protein Expression and Purification, 2002Recombinant human microsomal prostaglandin E(2) synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell membranes with diheptanoylphosphatidylcholine and purified in the presence of octylglucoside using hydroxyapatite column chromatography.
Marc, Ouellet +6 more
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A Novel Type of Membrane-Associated Prostaglandin E Synthase
2003Prostaglandin (PG) E2 is widely distributed in various organs, and exhibits various biologically important activities such as smooth muscle dilatation/contraction, body temperature regulation, induction of pain, stimulation of bone resorption, and inhibition of immune responses. PGE synthase catalyzes the conversion of PGH2 to PGE2. About 25 years ago,
Kikuko, Watanabe +5 more
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Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
Pharmacological Reviews, 2007Prostaglandin E(2) (PGE(2)) is the most abundant prostaglandin in the human body. It has a large number of biological actions that it exerts via four types of receptors, EP1-4. PGE(2) is formed from arachidonic acid by cyclooxygenase (COX-1 and COX-2)-catalyzed formation of prostaglandin H(2) (PGH(2)) and further transformation by PGE synthases.
Bengt, Samuelsson +2 more
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Prostaglandin E Synthase: A Novel Drug Target for Inflammation and Cancer
Current Pharmaceutical Design, 2006Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H(2) to PGE(2), occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions.
Makoto, Murakami, Ichiro, Kudo
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Prostaglandin E2synthase inhibition as a therapeutic target
Expert Opinion on Therapeutic Targets, 2009Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2. Since COX-1 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycloxy genases leads to moderate to severe gastro-intestinal intolerance.
Jitesh P, Iyer +4 more
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Distribution of microsomal prostaglandin E synthase‐1 in the mouse brain
Journal of Comparative Neurology, 2014ABSTRACTPrevious studies in rats have demonstrated that microsomal prostaglandin E synthase‐1 (mPGES‐1) is induced in brain vascular cells that also express inducible cyclooxygenase‐2, suggesting that such cells are the source of the increased PGE2 levels that are seen in the brain following peripheral immune stimulation, and that are associated with ...
Anna, Eskilsson +3 more
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Marked expression of prostaglandin E synthases in endometriosis
Fertility and Sterility, 2008C. Carli +5 more
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