Results 41 to 50 of about 15,910 (222)
Detecting substeps in the rotary motors of FoF1-ATP synthase by Hidden Markov Models [PDF]
, 2007 FoF1-ATP synthase is the enzyme that provides the 'chemical energy currency' adenosine triphosphate, ATP, for living cells. The formation of ATP is accomplished by a stepwise internal rotation of subunits within the enzyme. We monitor subunit rotation by a single-molecule fluorescence resonance energy transfer (FRET) approach using two fluorophores ...
arxiv +1 more source
Monitoring the rotary motors of single FoF1-ATP synthase by synchronized multi channel TCSPC [PDF]
, 2007 Confocal time resolved single-molecule spectroscopy using pulsed laser excitation and synchronized multi channel time correlated single photon counting (TCSPC) provides detailed information about the conformational changes of a biological motor in real time.
arxiv +1 more source
Modeling work-speed-accuracy trade-offs in a stochastic rotary machine [PDF]
Phys. Rev. E 101, 032110 (2020), 2019 Molecular machines are stochastic systems that catalyze the energetic processes keeping living cells alive and structured. Inspired by the examples of F1-ATP synthase and the bacterial flagellum, we present a minimal model of an externally driven stochastic rotary machine.
arxiv +1 more source
The Membrane Binding Domains of Prostaglandin Endoperoxide H Synthases 1 and 2
Journal of Biological Chemistry, 1999 Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 and -2) are the major targets of nonsteroidal anti-inflammatory drugs. Both isozymes are integral membrane proteins but lack transmembrane domains.
A. Spencer +7 more
semanticscholar +1 more source
Journal of Biological Chemistry, 1998 Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) are the major targets of nonsteroidal anti-inflammatory drugs like aspirin and ibuprofen.
A. Spencer +4 more
semanticscholar +1 more source
Periodontology 2000, EarlyView.Abstract This systematic review aimed to evaluate all available evidence across all fields of medicine regarding the comparative effectiveness of platelet‐rich plasma (PRP) versus injectable platelet‐rich fibrin (i‐PRF). A comprehensive search was conducted in PubMed, Scopus, and Web of Science up to September 30, 2024.
Nima Farshidfar +6 more
wiley +1 more source
Reactions of Prostaglandin Endoperoxide Synthase and Its Compound I with Hydroperoxides [PDF]
Journal of Biological Chemistry, 1996 The reactions of native prostaglandin endoperoxide synthase with structurally different hydroperoxides have been investigated by using kinetic spectrophotometric scan and conventional and sequential mixing stopped-flow experiments. The second order rate constants for compound I formation are (5.9 +/- 0.1) x 10(4) M-1 s-1 using t-butyl hydroperoxide as ...
Marica Bakovic, H. B. Dunford
openaire +3 more sources
Therapeutic targeting of TGF‐β in lung cancer
The FEBS Journal, Volume 292, Issue 7, Page 1520-1557, April 2025.Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi +9 more
wiley +1 more source
Electric Field Driven Torque in ATP Synthase [PDF]
Miller, J.H., Jr., Rajapakshe, K.I., Infante, H.L. & Claycomb,
J.R. Electric Field Driven Torque in ATP Synthase. PLoS ONE 8, e74978 (2013), 2013 Fo-ATP synthase (Fo) is a rotary motor that converts potential energy from ions, usually protons, moving from high- to low-potential sides of a membrane into torque and rotary motion. Here we propose a mechanism whereby electric fields emanating from the proton entry and exit channels act on asymmetric charge distributions in the c-ring, due to ...
arxiv +1 more source
Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance
Molecular Oncology, Volume 19, Issue 3, Page 592-613, March 2025.Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela +2 more
wiley +1 more source