Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis [PDF]
Translational Neurodegeneration, 2023 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cord is a focus ...
Hiroshi Nango +5 more
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Replication of Marek's Disease Virus Is Dependent on Synthesis of De Novo Fatty Acid and Prostaglandin E 2 [PDF]
, 2019 Marek’s disease virus (MDV) causes deadly lymphoma and induces an imbalance of the lipid metabolism in infected chickens. Here, we discovered that MDV activates the fatty acid synthesis (FAS) pathway in primary chicken embryo fibroblasts (CEFs).
Nitish Boodhoo +3 more
openalex +4 more sources
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
doaj +1 more source
PTGER4 expression-modulating polymorphisms in the 5p13.1 region predispose to Crohn's disease and affect NF-κB and XBP1 binding sites. [PDF]
, 2012 Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort of patients with inflammatory bowel disease (
Achkar, Jean-Paul +14 more
core +11 more sources
Insights into the prostanoid pathway in the ovary development of the penaeid shrimp Penaeus monodon. [PDF]
PLoS ONE, 2013 The prostanoid pathway converts polyunsaturated fatty acids (PUFAs) into bioactive lipid mediators, including prostaglandins, thromboxanes and prostacyclins, all of which play vital roles in the immune and reproductive systems in most animal phyla.
Wananit Wimuttisuk +6 more
doaj +1 more source
Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. [PDF]
PLoS ONE, 2011 Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis,
Josef Anrather +7 more
doaj +1 more source
Pulmonary surfactant and prostaglandin E2 in airway smooth muscle relaxation of human and male guinea pigs. [PDF]
Physiol RepHanusrichterova J +14 more
europepmc +2 more sources
Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. [PDF]
PLoS ONE, 2012 Sulforaphane (SFN) is a dietary cancer preventive with incompletely characterized mechanism(s) of cancer prevention. Since prostaglandin E2 (PGE2) promotes cancer progression, we hypothesized that SFN may block PGE2 synthesis in cancer cells.
Jiping Zhou +3 more
doaj +1 more source
Children, 2022 Objective: To assess the oxidant and antioxidant status in neonates with and without hyperbilirubinemia and their association with early manifestations of acute bilirubin encephalopathy (ABE), in addition to eliciting the possible oxidative effects of ...
Dina Abdel Razek Midan +3 more
doaj +1 more source
SAGE Open Medicine, 2020 Objectives: Symptoms of sore throat result from oropharyngeal inflammation, for which prostaglandin E 2 is a key mediator. Flurbiprofen is a non-steroidal anti-inflammatory that provides sore throat relief.
Rob Lambkin-Williams +2 more
doaj +1 more source