Results 1 to 10 of about 346,856 (222)
Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
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Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis [PDF]
Translational Neurodegeneration, 2023 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cord is a focus ...
Hiroshi Nango +5 more
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Insights into the prostanoid pathway in the ovary development of the penaeid shrimp Penaeus monodon. [PDF]
PLoS ONE, 2013 The prostanoid pathway converts polyunsaturated fatty acids (PUFAs) into bioactive lipid mediators, including prostaglandins, thromboxanes and prostacyclins, all of which play vital roles in the immune and reproductive systems in most animal phyla.
Wananit Wimuttisuk +6 more
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Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. [PDF]
PLoS ONE, 2011 Cyclooxygenases (COX) are prostanoid synthesizing enzymes constitutively expressed in the brain that contribute to excitotoxic neuronal cell death. While the neurotoxic role of COX-2 is well established and has been linked to prostaglandin E(2) synthesis,
Josef Anrather +7 more
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Prostaglandin E Receptors [PDF]
Journal of Biological Chemistry, 2007 Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction, tissue localization, and regulation of expression ...
Yukihiko Sugimoto, Shuh Narumiya
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Prostaglandin E Synthases in Zebrafish [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— Prostaglandin E synthases (PGESs) are being explored as antiinflammtory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE 2 formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation ...
Pini, Barbara +5 more
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Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis [PDF]
BMB Reports, 2005 Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties ...
Makoto Murakami, Ichiro Kudo
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Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. [PDF]
PLoS ONE, 2012 Sulforaphane (SFN) is a dietary cancer preventive with incompletely characterized mechanism(s) of cancer prevention. Since prostaglandin E2 (PGE2) promotes cancer progression, we hypothesized that SFN may block PGE2 synthesis in cancer cells.
Jiping Zhou +3 more
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SAGE Open Medicine, 2020 Objectives: Symptoms of sore throat result from oropharyngeal inflammation, for which prostaglandin E 2 is a key mediator. Flurbiprofen is a non-steroidal anti-inflammatory that provides sore throat relief.
Rob Lambkin-Williams +2 more
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Children, 2022 Objective: To assess the oxidant and antioxidant status in neonates with and without hyperbilirubinemia and their association with early manifestations of acute bilirubin encephalopathy (ABE), in addition to eliciting the possible oxidative effects of ...
Dina Abdel Razek Midan +3 more
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