Results 11 to 20 of about 4,872 (106)

Prostaglandin E-major urinary metabolite diagnoses mucosal healing in patients with ulcerative colitis in remission phase. [PDF]

J Gastroenterol Hepatol, 2022
AbstractBackground and AimUlcerative colitis (UC) is usually detected by clinical symptoms, such as bleeding and diarrhea; however, it is rather difficult to assess during asymptomatic clinical remission (CR). Hence, there is a need for a biomarker that can reliably detect UC during remission.
Sakurai T, Akita Y, Miyashita H, Miyazaki R, Maruyama Y, Saito T, Shimada M, Yamasaki T, Arhihiro S, Kato T, Matsuura T, Ikegami M, Okayasu I, Saruta M.   +13 more
europepmc   +5 more sources

Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer. [PDF]

Interdiscip Cardiovasc Thorac Surg, 2023
AbstractOBJECTIVESCyclooxygenase-2-derived prostaglandin E2 (PGE2) is highly involved in the promotion of cancer progression. The end product of this pathway, PGE-major urinary metabolite (PGE-MUM), is a stable metabolite of PGE2 that can be assessed non-invasively and repeatedly in urine samples. The aim of this study was to assess the dynamic changes
Mikubo M, Satoh Y, Ono M, Sonoda D, Hayashi S, Naito M, Matsui Y, Shiomi K, Matsuura M, Ito S.   +9 more
europepmc   +3 more sources

Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma. [PDF]

Cancers (Basel), 2019
Background: Prostaglandin E2 (PGE2) is metabolized to prostaglandin E-major urinary metabolite (PGE-MUM). Enhanced cyclooxygenase-2 (COX-2) expression demonstrated in lung adenocarcinoma indicates increased PGE-MUM levels in patients with lung adenocarcinoma. Objectives: We aimed to elucidate the clinical usefulness of measuring PGE-MUM as an indicator
Kawamoto H, Hara H, Araya J, Ichikawa A, Fujita Y, Utsumi H, Hashimoto M, Wakui H, Minagawa S, Numata T, Arihiro S, Matsuura T, Fujiwara M, Ito S, Kuwano K.   +14 more
europepmc   +5 more sources

Prostaglandin E-Major Urinary Metabolite Predicts Relapse in Patients With Ulcerative Colitis in Clinical Remission. [PDF]

Clin Transl Gastroenterol, 2020
INTRODUCTION:Prostaglandin E-major urinary metabolite (PGE-MUM) is a novel biomarker reflecting endoscopic activity in ulcerative colitis (UC). However, there are no studies investigating the efficacy of PGE-MUM as a biomarker for predicting relapse. We investigated whether PGE-MUM can predict clinical relapse of UC.METHODS:The measurement of PGE-MUM ...
Ishida N, Sugiura K, Miyazu T, Tamura S, Suzuki S, Tani S, Yamade M, Iwaizumi M, Hamaya Y, Osawa S, Furuta T, Sugimoto K.   +11 more
europepmc   +3 more sources

Predicting Ulcerative Colitis Relapse in Clinical Remission With Fecal Immunochemical Occult Blood Test or Prostaglandin E-Major Urinary Metabolite. [PDF]

Clin Transl Gastroenterol, 2022
INTRODUCTION: The fecal immunochemical occult blood test (FIT) and prostaglandin E-major urinary metabolite (PGE-MUM) have been reported to predict the relapse of ulcerative colitis (UC) during remission. In this study, we directly compared FIT and PGE-MUM in predicting relapse and examined the effect of disease duration on ...
Ishida N, Matsuura T, Asai Y, Miyazu T, Tamura S, Tani S, Yamade M, Iwaizumi M, Hamaya Y, Osawa S, Furuta T, Sugimoto K.   +11 more
europepmc   +3 more sources

Age-related variations in prostaglandin E-major urinary metabolite values in Japanese children. [PDF]

Pediatr Int
Abstract Background Prostaglandin E‐major urinary metabolite (PGE‐MUM) is an emerging noninvasive biomarker used to evaluate clinical and endoscopic activity in patients with inflammatory bowel disease.
Maeyama T, Takashiba A, Hata A, Hizuka K, Saura R, Etani Y, Hagiwara SI.   +6 more
europepmc   +4 more sources

Evaluation of a Chemiluminescent Enzyme Immunoassay for the Detection of Prostaglandin E-Major Urinary Metabolite (PGE-MUM). [PDF]

J Clin Lab Anal
ABSTRACTBackgroundWe developed a fully automated quantitative immunoassay for the detection of prostaglandin E‐major urinary metabolite (PGE‐MUM). In this study, we evaluated the analytical performance of this assay.MethodsSensitivity, within‐run reproducibility, correlation with radioimmunoassay (RIA), cross‐reactivity, dilution linearity, spike ...
Takagi J, Moriyama K, Arihiro S, Kato T, Sakurai T, Saruta M, Wakabayashi M, Nasu H, Katagiri N, Yagi S, Yagi S.   +10 more
europepmc   +3 more sources

Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in active mesenteric panniculitis patients: A case report. [PDF]

Medicine (Baltimore), 2017
Mesenteric panniculitis (MP) is a rare disease with abdominal and systemic symptoms and is characterized by nonspecific inflammation, fat necrosis, and fibrosis in mesenteric fat. Active inflammatory responses may increase levels of prostaglandin E-major urinary metabolite (PGE-MUM), which was reported to reflect the disease activity of ulcerative ...
Mizuno S, Wakui M, Machida Y, Hosoe N, Hisamatsu T, Ishida T, Kameyama K, Naganuma M, Kanai T.   +8 more
europepmc   +3 more sources

Determining the Treatment Strategy for Refractory Ulcerative Colitis Using Prostaglandin E-major Urinary Metabolite (PGE-MUM) Measurement. [PDF]

Cureus
Prostaglandin E-major urinary metabolite (PGE-MUM) is a valuable biomarker reflecting the cytokine profile. We encountered a case of a 14-year-old boy with pan-colitis-type ulcerative colitis who was unresponsive to steroids and infliximab. The patient's clinical symptoms gradually deteriorated and surgical treatment was strongly considered because ...
Miyamoto R, Honma H, Masuda Y, Ito Y, Okumura A.   +4 more
europepmc   +3 more sources

Significant increase of prostaglandin E-major urinary metabolite in male smokers: a screening study of age and gender differences using a simple radioimmunoassay. [PDF]

J Clin Lab Anal, 2014
BackgroundFor the assessment of inflammatory status, we have developed a simple, reliable radioimmunoassay (RIA) of prostaglandin E‐major urinary metabolite (PGE‐MUM), which remains stable in urine after it is metabolized. Using this method, we conducted a screening study to compare standard values of PGE‐MUM to serum C‐reactive protein (CRP) levels in
Okayasu I, Ohnishi H, Sarandi I, Shojima J, Komatsu J, Oritsu M, Sasabe M, Nanami KO, Matsuura M, Azumi J, Ito S, Fujiwara M.   +11 more
europepmc   +4 more sources