Interleukin 1 Signaling Is Regulated by Leukemia Inhibitory Factor (LIF) and Is Aberrant in Lif−/− Mouse Uterus [PDF]
, 2008 This study addresses the regulation of the interleukin 1 (IL1) system in the murine uterine luminal epithelium (LE) and stroma by leukemia inhibitory factor (LIF). Using RT-PCR we compared expression of Il1a, Il1b, Il1rn, Il1r1, and Il1r2 during the pre-
Heath, John K
core
Animal Research and One Health, EarlyView.Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian +8 more
wiley +1 more source
Prostaglandin E 2 Mediates Connecting Tubule Glomerular Feedback [PDF]
, 2013 Yilin Ren +4 more
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Arthritis &Rheumatology, EarlyView.Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham +15 more
wiley +1 more source
Resetting of peripheral circadian clock by prostaglandin E 2 [PDF]
, 2005 Yoshiki Tsuchiya +3 more
openalex +1 more source
Arthritis &Rheumatology, EarlyView.Objective This study aims to investigate the impact of nonsteroidal anti‐inflammatory drug (NSAID) intake on radiographic spinal progression in axial spondyloarthritis (axSpA), considering different NSAID types (COX‐2 inhibitors [COX2i] and nonselective NSAIDs [ns‐NSAIDs]) and disease subgroups (radiographic [r‐axSpA] and nonradiographic [nr‐axSpA ...
Murat Torgutalp +8 more
wiley +1 more source
Hyperpolarization and slowing of the rate of contraction in human uterus in pregnancy by prostaglandins E2 and F2α: involvement of the Na+ pump [PDF]
, 1999 Helena C. Parkington +4 more
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Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, Accepted Article.Background ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. Objective To evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired thrombo‐inflammatory ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
Navigating adverse immunostimulation: A practical guide for clinical researchers
British Journal of Clinical Pharmacology, EarlyView.Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort +3 more
wiley +1 more source
Expression of cyclo-oxygenase 1 and 2, prostaglandin E synthase and transforming growth factor β1, and their relationship with vascular endothelial growth factors A and C, in primary adenocarcinoma of the small intestine [PDF]
, 2006 Burkhard H.A. von Rahden +5 more
openalex +1 more source