Metabolomic analysis reveals the molecular mechanism related to leg abnormality in broilers
The graphical abstract shows the principal results of this study. Compared to the leg normal broilers, the serum calcium to phosphorus ratio was extremely decreased in the group with deformed leg bones. Additionally, a total of nine differential metabolites significantly associated with leg abnormalities and serum calcium and phosphorus levels were ...
Jumei Zheng+9 more
wiley +1 more source
A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus [PDF]
R. Paul Robertson, Mei Chen
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Objective Chondrocytemetabolic dysfunction plays an important role in osteoarthritis (OA) development during aging and obesity. Protein posttranslational modifications (PTMs) have recently emerged as an important regulator of cellular metabolism. We aim to study one type of PTM, lysine malonylation (MaK), and its regulator sirtuin 5 (Sirt5) in OA ...
Huanhuan Liu+11 more
wiley +1 more source
Visual quantification of prostaglandin E2 discharge from a single cell. [PDF]
Watabe T+3 more
europepmc +1 more source
Followup Results of a Combination of Calcitonin Gene-Related Peptide and Prostaglandin E1 in the Treatment of erectile Dysfunction. [PDF]
Aboseif+29 more
core +1 more source
AAD-2004, a potent spin trapping molecule and microsomal prostaglandin E synthase-1 inhibitor, shows safety and efficacy in a mouse model of ALS [PDF]
While free radicals and inflammation constitute major routes of neuronal injury occurring in neurodegenerative diseases, neither antioxidants nor nonsteroidal anti-inflammatory drugs (NSAIDs) have shown significant efficacy in human clinical trials.
Bok Yun+12 more
core +1 more source
Gout and NLRP3 Inflammasome Biology
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley +1 more source
Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease. [PDF]
Kotsos D, Tziomalos K.
europepmc +1 more source
The effects of prostaglandins E1, F1α and F2α on monosynaptic reflexes
P Duda, E. W. HORTON, Angus McPherson
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Prostaglandin and thromboxane synthesis in a pure macrophage population and the inhibition, by E‐type prostaglandins, of chemiluminescence [PDF]
Maurice J. Weidemann+5 more
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