Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background The effects of phosphodiesterase 5 (PDE5) inhibitors on the incidence of long‐term outcomes in patients with cardiovascular disease are not well understood. Objective: We studied the association between PDE5 inhibitor therapy and the incidence of adverse cardiovascular major adverse cardiovascular events (MACE) in patients ...
Sumon Roy +5 more
wiley +1 more source
Harnessing prostaglandin E2 signaling to ameliorate autoimmunity. [PDF]
Trends Immunol, 2023 Burkett JB, Doran AC, Gannon M.
europepmc +1 more source
EFFECTS OF PROSTAGLANDIN E2 AND A PROSTAGLANDIN ENDOPEROXIDE ANALOGUE ON NEUROEFFECTOR TRANSMISSION IN THE RAT ANOCOCCYGEUS MUSCLE [PDF]
, 1978 KHAWLA S. AL TIMIMI +2 more
openalex +1 more source
Shifting the Substrate Scope of an Ene/Yne‐Reductase by Loop Engineering
ChemCatChem, EarlyView.A flexible active‐site loop that is involved in shaping the substrate and product cleft as well as the active‐site pocket was identified for the MDR‐related ene/yne‐reductase CaeEnR1 from Cyclocybe aegerita. Double mutations of this loop showed an up to 20‐fold increase in conversion rates toward cinnamaldehyde‐like substrates and a 2‐fold increase in ...
Dominik Karrer +7 more
wiley +1 more source
Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke. [PDF]
Neurotherapeutics, 2022 Li L +7 more
europepmc +1 more source
Specific Binding of Prostaglandins E2and F2αby Membrane Preparations from Rat Skin* [PDF]
, 1978 Jonathan T. Lord +2 more
openalex +1 more source
Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes
ChemElectroChem, EarlyView.This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský +5 more
wiley +1 more source
THE EFFECTS OF PROSTAGLANDINS E1, E2 AND F2α ON THE CUTANEOUS VASCULATURE OF THE RAT [PDF]
, 1976 Loris A. Chahl, Rachel Ladd
openalex +1 more source
Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities
ChemMedChem, EarlyView.Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia +4 more
wiley +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source