Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2. [PDF]
Arthritis research & therapy, 2005 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Seetha U. Monrad +2 more
openaire +7 more sources
Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis [PDF]
Translational Neurodegeneration, 2023 Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. The pathogenesis of ALS remains largely unknown; however, inflammation of the spinal cord is a focus ...
Hiroshi Nango +5 more
doaj +2 more sources
Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia [PDF]
, 2009 Background: The majority of acute myeloid leukaemia (AML) patients are over sixty years of age. With current treatment regimens, survival rates amongst these, and also those younger patients who relapse, remain dismal and novel therapies are urgently ...
Alessia Lodi +15 more
core +16 more sources
Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]
, 2011 Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Nicolaou, A +3 more
core +7 more sources
Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: An Advanced Treatment Modality for Autologous Cell Therapy [PDF]
, 2009 Aims: The mobilization of endothelial progenitor cells (EPC) and their functioning in postnatal neovascularization are tightly regulated. To identify new modulators of EPC homeostasis, we screened biologically active prostaglandin E compounds for their ...
Heeschen, Christopher +6 more
core +1 more source
PENGARUH PEMBERIAN VITAMIN E TERHADAP KADAR PROSTAGLANDIN (PGF2α) DAN TNF α PADA PENDERITA DISMENOREA [PDF]
, 2019 Pemberian vitamin E pada wanita yang mengalami dismenorea dapat secara langsung menekan kadar ROS dan dapat memperbaiki struktur memberan sel yang rusak. Penelitian ini bertujuan untuk membuktikan pengaruh pemberian vitamin E terhadap kadar Prostaglandin
Basyir, Vaulinne, Rishel, Rika Astria
core +2 more sources
Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers [PDF]
, 2003 Background/Aim: N-6 fatty acids are considered to promote diseases prevalent in industrialized countries and characterized by an increased eicosanoid biosynthesis from arachidonic acid (AA).
Adam, Olaf, Wolfram, G., Zöllner, N.
core +1 more source
Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]
, 2006 Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S. +7 more
core +1 more source
PLoS ONE, 2021 Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown.
Nanase Takahashi +9 more
doaj +1 more source
The mechanism and mitigation of niacin-induced flushing [PDF]
, 2009 AimsTo summarise the metabolic responses to niacin that can lead to flushing and to critically evaluate flushing mitigation research.Methods and resultsThis comprehensive review of the mechanism of action of niacin-induced flushing critically evaluates ...
Andersson +71 more
core +2 more sources