Results 11 to 20 of about 346,955 (321)

Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity

open access: yesNature Communications, 2023
Prostaglandins and their receptors regulate various physiological processes. Carboprost, an analog of prostaglandin F2α and an agonist for the prostaglandin F2-alpha receptor (FP receptor), is clinically used to treat postpartum hemorrhage (PPH). However,
Xiuqing Lv   +12 more
doaj   +1 more source

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor.

open access: yesPLoS ONE, 2021
Prostaglandin E2 (PGE2) is known to have important roles in labor, but the detailed mechanism underlying the spontaneous human labor remains unknown.
Nanase Takahashi   +9 more
doaj   +1 more source

Reciprocal interactions between prostaglandin E2- and estradiol-dependent signaling pathways in the injured zebra finch brain

open access: yesJournal of Neuroinflammation, 2017
Background Astrocytic aromatization and consequent increases in estradiol are neuroprotective in the injured brain. In zebra finches, cyclooxygenase-activity is necessary for injury-induced aromatase expression, and increased central estradiol lowers ...
Alyssa L. Pedersen, Colin J. Saldanha
doaj   +1 more source

Clinical Significance of Prostaglandins in the Formation of Courses of Bacterial Intestinal Infections in Children

open access: yesZdorovʹe Rebenka, 2015
The levels of prostaglandin E and prostaglandin F2α in the blood serum of infants with bacterial intestinal infections have been investigated. The connection between increased indexes during acute phase of the disease and the type of its course has been ...
T.S. Zharkova
doaj   +1 more source

Multi‐omics analyses reveal the interaction between colonic microbiota and host in Min and Yorkshire pigs

open access: yesAnimal Research and One Health, EarlyView., 2023
In the present study, we created the weight gain models with Min and Yorkshire pigs and conducted the metagenomics and metabolomics of colon contents and transcriptomics of colon tissue. Further, we revealed the characteristics and functions of the colonic microbiota in Min and Yorkshire pigs and analyzed their interactions with the host. Overall, this
Xiaoyu Huang   +6 more
wiley   +1 more source

Modeling of biological doses and mechanical effects on bone transduction [PDF]

open access: yesJournal of Theoretical Biology 274, 1 (2011) 36-42, 2011
Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone.
arxiv   +1 more source

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.

open access: yesArthritis research & therapy, 2005
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Seetha U. Monrad   +2 more
openaire   +3 more sources

Prostaglandin cyclooxygenase products but not thromboxane A2 are involved in the pathogenesis of ewthromelalgia in thrombocythaemia

open access: yesMediators of Inflammation, 1993
Fluid of artificial blisters from erythromelalgic skin areas in primary thrombocythaemia contained a high amount of prostaglandin-E-like activity. Dazoxiben did not alleviate the erythromelalgia in patients with primary thrombocythaemia despite complete ...
J. J. Michiels, F. J. Zijlstra
doaj   +1 more source

PAF‐induced inflammatory and immuno‐allergic ophthalmic diseases and their mitigation with PAF receptor antagonists: Cell and nuclear effects

open access: yesBioFactors, Volume 48, Issue 6, Page 1226-1249, November/December 2022., 2022
Abstract Ocular allergies are becoming more prevalent as more airborne pollutants, irritants and microbes pervade our environment. Inflammatory and allergic mediators released by dendritic and mast cells within the conjunctiva cause allergic conjunctivitis (AC), a prevalent ocular surface disorder that affects >40% of the world's human population on a ...
Najam A. Sharif
wiley   +1 more source

The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs

open access: yesBMC Veterinary Research, 2012
Background The objective was to determine the effects of agility exercise on dogs of different skill levels with respect to urinary eicosanoids, urinary 15F2t-isoprostane (lipid peroxidation marker) and hematological/biochemical changes in plasma ...
Baltzer Wendy I   +5 more
doaj   +1 more source

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