Results 211 to 220 of about 346,955 (321)

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi   +17 more
wiley   +1 more source

Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy

open access: yesFASEB BioAdvances, Volume 4, Issue 12, Page 775-797, December 2022., 2022
Abstract During initial maternal recognition of pregnancy (MRP), the equine embryo displays a series of unique events characterized by rapid blastocyst expansion, secretion of a diverse array of molecules, and transuterine migration to interact with the uterine surface.
Alba Rudolf Vegas   +6 more
wiley   +1 more source

Exploring the Role of T‐Cell Metabolism in Modulating Immunotherapy Efficacy for Non‐Small Cell Lung Cancer Based on Clustering

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
We conducted a comprehensive investigation of the metabolic profiles of infiltrating T cells in NSCLC tumors and found metabolic heterogeneity in three T‐cell subtypes, which are associated with the prognosis of ICB therapy. We defined these metabolic clusters as response‐dependent (R) clusters and non‐response‐dependent (NR) clusters, and elucidated ...
Hongzhe Guo   +7 more
wiley   +1 more source

A Retrospective Analysis of PK and Response of Oral Ibuprofen in the Treatment of a Patent Ductus Arteriosus in Extremely Low Gestational Age Neonates

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Oral ibuprofen is the preferred pharmacotherapeutic option for treatment of a persistent patent ductus arteriosus (PDA), but evidence for its optimal use in extremely low gestational age newborns (ELGANs) remains limited. In the current study, we aimed to investigate the pharmacokinetics and exposure‐response relationship of oral ibuprofen in ...
Mohd Asif   +6 more
wiley   +1 more source

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