Results 101 to 110 of about 243,841 (348)

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Chain length specificity for activation of cPLA2α by C1P: use of the dodecane delivery system to determine lipid-specific effects

Journal of Lipid Research, 2009
Previously, our laboratory demonstrated that ceramide-1-phosphate (C1P) specifically activated group IVA cytosolic phospholipase A2 (cPLA2α) in vitro. In this study, we investigated the chain length specificity of this interaction. C1P with an acyl-chain
Dayanjan S. Wijesinghe, Preeti Subramanian, Nadia F. Lamour, Luciana B. Gentile, Maria H. Granado, Alicja Bielawska, Zdzislaw Szulc, Antonio Gomez-Munoz, Charles E. Chalfant   +8 more
doaj   +1 more source

Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. [PDF]

, 2020
In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating ...
Bazinet, Richard P, Hammock, Bruce D, Metherel, Adam H, Newman, John W, Otoki, Yurika, Pedersen, Theresa, Taha, Ameer Y, Yang, Jun   +7 more
core   +1 more source

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

Advanced Science, EarlyView.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao, Qing Li, Xiaowu Bai, Ertao Zhai, Weigang Dai, Yan Qian, Tianhao Zhang, Zhixin Huang, Ziyu Huang, Fangang Meng, Jianhui Chen, Tao Zuo, Shirong Cai, Risheng Zhao   +13 more
wiley   +1 more source

Functional and Morphological Characterization of Small and Large Steroidogenic Luteal Cells From Domestic Cats Before and During Culture

Frontiers in Endocrinology, 2019
The current study aimed to isolate, culture and characterize small (SLC) and large (LLC) steroidogenic cells from the corpora lutea (CL) of non-pregnant domestic cats.
Michał M. Hryciuk, Beate C. Braun, Liam D. Bailey, Katarina Jewgenow   +3 more
doaj   +1 more source

The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor [PDF]

, 2020
Chess-Williams, Russ, Moro, Christian, Stromberga, Zane   +2 more
core   +1 more source

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium [PDF]

, 2017
Adaptive cellular responses are often required during wound repair. Following disruption of the intestinal epithelium, wound‐associated epithelial (WAE) cells form the initial barrier over the wound.
Lai, Chin-Wen, Malvin, Nicole P, Miyoshi, Hiroyuki, Ryu, Stacy H, Sonnek, Naomi M, Stappenbeck, Thaddeus S, VanDussen, Kelli L, Wang, Yi   +7 more
core   +2 more sources

Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells [PDF]

, 2017
Garrett C. Heffner, Melissa Bonner, Lauryn Christiansen, Francis J. Pierciey, Dakota Campbell, Yegor Smurnyy, Wenliang Zhang, Amanda Hamel, Seema Shaw, Gretchen Lewis, Kendrick A. Goss, Olivia Garijo, Bruce E. Torbett, Holly M. Horton, Mitchell Finer, Philip D. Gregory, Gábor Veres   +16 more
openalex   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Prostaglandin F2-alpha receptor regulation in human uterine myocytes [PDF]

, 2008
Zhi-qing Liang, Suren R. Sooranna, N. Engineer, Mark Tattersall, Shirin Khanjani, Phillip R. Bennett, Leslie Myatt, Mark R. Johnson   +7 more
openalex   +1 more source