Results 111 to 120 of about 114,931 (296)
Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source
Actions of prostaglandins on isolated perfused cat coronary arteries
, 1978 Effects of prostaglandins on coronary arterial smooth muscle were studied in isolated perfused cat coronary arteries. This preparation was shown to be responsive to known vasoactive agents, including angiotensin II, adenosine, and norepinephrine ...
M. L. Ogletree, A. M. Lefer, J. B. Smith
core +1 more source
Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta
Clinical Pharmacology &Therapeutics, EarlyView.Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus. The placenta is also responsible for the uptake and/or exchange of xenobiotics, including medications, between the maternal and fetal bloodstreams. An estimated 40–80% of women take medications or drugs during pregnancy.
Eric M. Weaver +6 more
wiley +1 more source
Cyclooxygenase-Deficient Pancreatic Cancer Cells Use Exogenous Sources of Prostaglandins
, 2010 Genes that are differentially expressed in pancreatic cancers and under epigenetic regulation are of considerable biological and therapeutic interest. We used global gene expression profiling and epigenetic treatment of pancreatic cell lines including ...
Michael Borges +7 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil +6 more
wiley +1 more source
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
, 2011 A new tissue-specific pathway for the synthesis of proinflammatory prostaglandins is described.
Jacqueline L. Blankman +10 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Studies on seminal prostaglandins [PDF]
, 1979 The lipid fraction of human semen has been separated by LH 20 Sephadex chromatography and TLC and the resulting fractions analysed by GCMS. Evidence is presented for the existence in semen of several prostaglandins, including 19 -OH PG F₁α, 19-OH PG ...
Taylor, Philip Leslie
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