Results 111 to 120 of about 64,031 (206)

15‐Hydroxy‐Prostanoate Dehydrogenase. Prostaglandins as Substrates and Inhibitors [PDF]

, 1969
Jiro Nakano, Erik Änggård, Bengt Samuelsson   +2 more
openalex   +1 more source

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

Molecular Informatics, Volume 41, Issue 12, December 2022., 2022
Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco, Gianluigi Lauro, Giuseppe Bifulco   +2 more
wiley   +1 more source

Antifertility Properties of Prostaglandin F2α [PDF]

, 1969
Garance Gutknecht, James C. Cornette, Bruce B. Pharriss   +2 more
openalex   +1 more source

A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin‐Converting Enzyme Inhibitors

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre, Annette D. Lista, Nick Paulson, Lorianne Masuoka   +3 more
wiley   +1 more source

The Structure of a Urinary Metabolite of Prostaglandin F1α in the Rat

, 1965
Elisabeth Granström, Ulf Inger, Bengt Samuelsson   +2 more
openalex   +1 more source

Phospholipid precursors of prostaglandins [PDF]

, 1968
William E.M. Lands, Bengt Samuelsson
openalex   +1 more source

Selective changes of docosahexaenoic acid-containing phospholipid molecular species in monkey testis during puberty

Journal of Lipid Research, 2004
Puberty has a profound effect upon the biochemical composition of the testis. We previously demonstrated that puberty was accompanied by great increases in the content of docosahexaenoic acid (DHA; 22:6 n-3) and dihomogamma-linoleic acid (20:3 n-6) and ...
Don S. Lin, Martha Neuringer, William E. Connor   +2 more
doaj  

Lipid and Corticosteroid Biomarkers Under the Influence of Bisphosphonates

Drug Testing and Analysis, EarlyView.
The detection of bisphosphonates is important due to the potential integrity and welfare issues associated with use of these substances. Targeted detection of a nitrogenous and non‐nitrogenous bisphosphonate was detected for 8 h and 28 days post‐administration, respectively.
Kathy Tou, Adam Cawley, Glenys Noble, Jaymie Loy, David Bishop, John Keledjian, Kireesan Sornalingam, Stacey Richards, Shanlin Fu   +8 more
wiley   +1 more source

Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms

Journal of Lipid Research, 2007
Previously, ceramide-1-phosphate (C1P) and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] were demonstrated to be potent and specific activators of group IVA cytosolic phospholipase A2 (cPLA2α). In this study, we hypothesized that these anionic lipids
Preeti Subramanian, Mohsin Vora, Luciana B. Gentile, Robert V. Stahelin, Charles E. Chalfant   +4 more
doaj  

Immune cell dynamics in heart failure: implicated mechanisms and therapeutic targets

ESC Heart Failure, EarlyView.
Abstract The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune ...
Gen Li, Wu He, Dao Wen Wang
wiley   +1 more source