Results 131 to 140 of about 363,420 (397)
Proceedings of the National Academy of Sciences of the United States of America, 1999 Mechanisms leading to down-regulation of activated microglia and astrocytes are poorly understood, in spite of the potentially detrimental role of activated glia in neurodegeneration.
T. Petrova, K. Akama, L. Eldik
semanticscholar +1 more source
Association between gingival crevicular fluid prostaglandin E 2 level and preterm low birth weight
Indian Journal of Dental Research, 2012 Background: Periodontal infections, which serve as a reservoir of inflammatory mediators such prostaglandin E 2 (PGE 2 ), may pose a threat to the fetal-placental unit and cause preterm delivery.
Fouzia Tarannum, Mohamed Faizuddin
doaj +1 more source
Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases
Advanced Science, Volume 12, Issue 14, April 10, 2025.This study presents carnosic acid (CA), an active ingredient of Rosmarinus officinalis L., dramatically ameliorates Trex1 deficiency‐mediated and STING‐dependent systemic inflammatory diseases by targeting STING C‐terminal tail (CTT) to disrupt STING activity.
Wenqing Mu +13 more
wiley +1 more source
Терапевтический архив, 2004 Aim. To study efficacy of colloid bismuth subcitrate (de-nol, Yamanuchi) in therapy of gastropathies provoked by nonsteroidal anti-inflammatory drugs (NSAID). Material and methods.
I V Maev, E S Vyuchnova, I V Staseva
doaj
Advanced Science, Volume 12, Issue 14, April 10, 2025.Pancreatic cancer promotes the accumulation of mast cells in the tumor microenvironment. Tumor‐derived exosomes deliver miR‐188‐5p to tumor‐associated mast cells (TAMCs), enhancing TAMCs‐derived CXCL10 secretion by strengthening ERG transcription. TAMCs‐derived CXCL10 promotes tumor migration, stemness, and immunosuppressive environment.
Hanlin Yin +20 more
wiley +1 more source
Dipyridamole Acts as Clinical Ferroptosis Inhibitor to Prevent from Tissue Injury
Advanced Science, EarlyView.Dipyridamole acts as a clinically used compound to suppress ferroptosis. Dipyridamole down‐regulates the expression of RNF126, which is an E3 ligase to ubiquitinate SLC7A11 for proteasome degradation. The deficiency of SLC7A11 largely abolishes the protective role of dipyridamole both in vitro and in vivo.
Xiao Zhuang +22 more
wiley +1 more source
Regulation of Dendritic Cell Function by Ermiaosan via the EP4-cAMP-CREB Signaling Pathway [PDF]
arXivErmiao San (EMS), a traditional Chinese medicine composed of Atractylodes macrocephala and Cortex Phellodendron, has demonstrated therapeutic efficacy in rheumatoid arthritis (RA). Studies suggest that EMS modulates dendritic cell (DC) maturation in adjuvant arthritis (AA) rats, though the precise mechanisms remain unclear.
arxiv
DISTRIBUTION OF PROSTAGLANDINS IN HUMAN TISSUES [PDF]
, 1967 S.M.M. Karim, M. Sandler, E. D. Williams
openalex +1 more source
Journal of Lipid Research, 2014 Arachidonic acid (AA) is a major PUFA that has been implicated in the regulation of adipogenesis. We examined the effect of a short exposure to AA at different stages of 3T3-L1 adipocyte differentiation.
Evanthia Nikolopoulou +6 more
doaj
Advanced Science, EarlyView.Hypothalamus sympathetic norepinephrine inhibits regeneration of articular cartilage. Mechanical loading on bone during animal activity elevates PGE2 skeletal interoception to promote an anabolic renewal of the superficial membrane by downregulation of norepinephrine for articular cartilage proper thickness and integrity.
Ziyi Wang +8 more
wiley +1 more source