Results 51 to 60 of about 114,931 (296)
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Biosynthesis of Prostaglandins [PDF]
Annual Review of Nutrition, 1991 Highly purified cyclooxygenase from sheep vesicular glands is stimulated by the presence of protoporphyrin IX compounds. This stimulation may be due to the conversion of an apoenzyme to the holoenzyme, and full activity is achieved when half of the enzyme subunits (70,000 daltons) bind heme.
openaire +2 more sources
Advanced Science, EarlyView.HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun +12 more
wiley +1 more source
Synthesis of prostaglandins and analogs
, 2001 Prostaglandins are an important class of biologically active compounds. The robust syntheses of different prostaglandins are of importance to the pharmaceutical industry. Synthesis should also be able to lead to various analogs. To aid in the development
Finnegan, David Francis
core +2 more sources
Dehydration of prostaglandins: study by spectroscopic method
Journal of Lipid Research, 1969 The ultraviolet (UV) and optical rotatory dispersion (ORD) spectra of prostaglandins E1, A1, B1, and their naturally derived 15-epimers are presented.
Niels H. Andersen
doaj +1 more source
Advanced Science, EarlyView.A nickel‐catalyzed three‐component reductive fluoroalkylation‐amination strategy of N‐vinylamides for the direct access to the α‐amidyl‐β‐difluoroalkyl amines was reported here. The synthetic method features with broad substrate scope, mild conditions, high functional group tolerance, and convenience to handle.
Chang Xu +8 more
wiley +1 more source
Studies of prostaglandins and prostaglandin antagonists on bovine pulmonary vein in vitro
LR: 20061115; PUBM: Print; JID: 0320271; 0 (Anthranilic Acids); 0 (Prostaglandin Antagonists); 0 (Prostaglandins); 108-88-3 (Toluene); 50-33-9 (Phenylbutazone); 50-67-9 (Serotonin); 50-78-2 (Aspirin); 51-45-6 (Histamine); 51-84-3 (Acetylcholine); 53-86-1
core +1 more source
Perfused prenodal lymphatics are constricted by prostaglandins
, 1991 Prostaglandins may contribute to the control of lymph flow by affecting lymphatic vessel contractility. We measured the pressure in perfused prenodal lymphatic vessel in the paw of the anesthetized dog as affected by administration of prostaglandins E1,
J. M. Dabney, D. E. Dobbins, M. J. Buehn
core +1 more source
Advanced Science, EarlyView.The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye +17 more
wiley +1 more source
Gastroenterologìa, 2018 Background. Digestive organ damage in patients with diabetes mellitus (DM) is based on several mechanisms: autonomic nervous system dysfunction, angiopathy, dysregulation of secretion and inactivation of hormones and increments.
Ye.S. Sirchak, M.P. Stan
doaj +1 more source