Results 101 to 110 of about 18,716,571 (404)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E

Current Issues in Molecular Biology
SARS-CoV-2 is an obligatory intracellular pathogen that requires a lipid bilayer membrane for its transport to build its nucleocapsid envelope and fuse with the host cell.
María Elena Soto, Linaloe Manzano-Pech, Verónica Guarner-Lans, Adrían Palacios-Chavarría, Rafael Ricardo Valdez-Vázquez, Raúl Martínez-Memije, Mohammed El-Hafidi, Félix Leao Rodríguez-Fierros, Israel Pérez-Torres   +8 more
doaj   +1 more source

A neurotoxicidade da Cannabis sativa e suas repercussões sobre a morfologia do tecido cerebral

ABCS Health Sciences, 2014
Para a compreensão das repercussões psicológicas e comportamentais verificadas em usuários de Cannabis sativa, experimentos têm sido desenvolvidos analisando a relação entre a intensidade do uso da droga e biomarcadores de lesão e inflamação. Dessa forma,
Bárbara da Silva Santos, Marcelo Coertjens   +1 more
doaj   +1 more source

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium [PDF]

, 2017
Adaptive cellular responses are often required during wound repair. Following disruption of the intestinal epithelium, wound‐associated epithelial (WAE) cells form the initial barrier over the wound.
Lai, Chin-Wen, Malvin, Nicole P, Miyoshi, Hiroyuki, Ryu, Stacy H, Sonnek, Naomi M, Stappenbeck, Thaddeus S, VanDussen, Kelli L, Wang, Yi   +7 more
core   +2 more sources

Metabolic regulation by prostaglandin E ₂ impairs lung group 2 innate lymphoid cell responses

, 2022
Calum T. Robb, You Zhou, Jennifer M. Felton, Birong Zhang, Marie Goepp, Privjyot Jheeta, Danielle J. Smyth, Rodger Duffin, Sonja Vermeren, Richard Breyer, Shuh Narumiya, Henry J. McSorley, Rick M. Maizels, Jürgen Schwarze, Adriano G. Rossi, Chengcan Yao   +15 more
openalex   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Cervical ripening methods for labor induction Métodos de preparo cervical para indução do trabalho de parto

Revista Brasileira de Saúde Materno Infantil, 2004
The indication for labor induction has been increasing in the world. It is known that cervical conditions are directly associated to the success of labor induction.
Fernanda Garanhani de Castro Surita, José Guilherme Cecatti, Fabiana Kruppa, Ricardo Porto Tedesco, Mary Ângela Parpinelli   +4 more
doaj   +1 more source

A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery [PDF]

, 2016
Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer.
Jones, Robert L., Kennedy, Simon, McCormick, Christopher, Mullen, Alexander B., Wadsworth, Roger M.   +4 more
core   +2 more sources

Rutin hydrate and extract from Castanopsis tribuloides reduces pyrexia via inhibiting microsomal prostaglandin E synthase-1

, 2022
Tarek Hasan, Esrat Jahan, Khondoker Shahin Ahmed, Hemayet Hossain, Syed Mumtahin Mannan Siam, Nusrat Nahid, Tanoy Mazumder, Md. Sadikur Rahman Shuvo, A F M Shahid Ud Daula   +8 more
openalex   +1 more source

Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin‐induced Intestinal Injury by Production of Carboxylesterase EstB

Advanced Science, EarlyView.
Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao, Qing Li, Xiaowu Bai, Ertao Zhai, Weigang Dai, Yan Qian, Tianhao Zhang, Zhixin Huang, Ziyu Huang, Fangang Meng, Jianhui Chen, Tao Zuo, Shirong Cai, Risheng Zhao   +13 more
wiley   +1 more source