Results 81 to 90 of about 32,037,930 (259)
Advanced Science, EarlyView.Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han +11 more
wiley +1 more source
Advanced Science, EarlyView.This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng +7 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 1997 The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p ...
Francisco das Chagas Medeiros +3 more
doaj +1 more source
Role of prostaglandins in regulating gastric motility
, 1984 Muscles of the stomach possess the ability to synthesize several prostaglandins. These compounds function as local regulatory agents by influencing the motor performance of the muscle cells.
K. M. Sanders
core +1 more source
Advanced Science, EarlyView.Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan +14 more
wiley +1 more source
Current Issues in Molecular BiologySARS-CoV-2 is an obligatory intracellular pathogen that requires a lipid bilayer membrane for its transport to build its nucleocapsid envelope and fuse with the host cell.
María Elena Soto +8 more
doaj +1 more source
Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance
Advanced Science, EarlyView.COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu +12 more
wiley +1 more source
B-ENTObjective: Pharyngocutaneous fistula (PCF) remains a major complication after laryngopharyngeal surgery. Experimental data investigating potential therapeutic agents for improving PCF healing are limited. This study aimed to establish a reproducible rat
Ali Adnan Özdemir +5 more
doaj +1 more source
Marine Drugs, 2019 Two new cembrane-type diterpenoids, lobophytins A (1) and B (3), and four new prostaglandins, (5E)-PGB2 (10), (5E)-13,14-dihydro-PGB2 (11), 13,14-dihydro-PGB2 (12) and 13,14-dihydro-PGB2-Me (13), together with ten known compounds were isolated from the ...
Hongjie Shen +8 more
doaj +1 more source
Advanced Science, EarlyView.Nuciferine directly binds the C2 domain of cPLA2, impairing its Ca2+‐dependent membrane translocation and activation. By suppressing arachidonic acid release and downstream pro‐inflammatory eicosanoid production, nuciferine attenuates NF‐κB signaling and inflammatory hepatocarcinogenesis, revealing cPLA2 as a direct molecular target underlying its ...
Jing Sun +12 more
wiley +1 more source