Results 81 to 90 of about 74,807 (316)

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon   +20 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

open access: yesHepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog   +12 more
wiley   +1 more source

Effects of misoprostrol on pentylenetetrazol-induced seizures in mice Efeitos de misoprostrol sobre convulsões induzidas por pentilenotetrazol em camundongos

open access: yesArquivos de Neuro-Psiquiatria, 1997
The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p ...
Francisco das Chagas Medeiros   +3 more
doaj   +1 more source

Control of neurotransmission by prostaglandins in canine trachealis smooth muscle.

open access: yes, 1984
Contractile responses of canine tracheal smooth muscle to electrical field stimulation diminished over a 2-h period of incubation. However, addition of indomethacin (10(-5) M) for a similar time not only prevented this inhibition of contractile response,
P. D. Graf   +6 more
core   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs   +4 more
wiley   +1 more source

Prostaglandins of the E-series inhibit connective tissue proliferation in the liver wound of the rat

open access: yes, 2005
The present study was undertaken to relate wound heating of an internal organ to prostaglandins of the E and F series. A small liver wound was induced by a galvanic cauter via the abdominal route under general anesthesia and prostaglandin E-1, E-2 and F ...
Selstam, Gunnar,   +3 more
core   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

open access: yesAdvanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo   +11 more
wiley   +1 more source

Synthetic studies towards the prostaglandins

open access: yes, 1978
The synthesis of an important intermediate (36) in a total synthesis of the prostaglandins was undertaken. Treatment of the monoanion of the pyrrolidine enamine of methyl acetoacetate with cis-4,5-epoxy-2(E)-decen-1-yl mesylate (42) followed by addition ...
Rickards, Gordon E.
core  

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu   +6 more
wiley   +1 more source

Preliminary Study on the Restoration of the Phospholipid Profile in Serum from Patients with COVID-19 by Treatment with Vitamin E

open access: yesCurrent Issues in Molecular Biology
SARS-CoV-2 is an obligatory intracellular pathogen that requires a lipid bilayer membrane for its transport to build its nucleocapsid envelope and fuse with the host cell.
María Elena Soto   +8 more
doaj   +1 more source

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