Results 1 to 10 of about 6,181 (127)
Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain [PDF]
Journal of Neuroinflammation, 2011 Background Although cyclooxygenases (COX) and prostaglandin E synthases (PGES) have been implicated in ischemic stroke injury, little is known about their role in intracerebral hemorrhage (ICH)-induced brain damage. This study examines the expression and
Wu He, Wu Tao, Wang Jessica, Wang Jian
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Upregulation of prostaglandin E by inducible microsomal prostaglandin E synthase-1 in colon cancer [PDF]
Annals of Coloproctology, 2022 Purpose Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin ...
Young Hun Kim, Kyung Jong Kim
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Prostaglandin E Synthases in Zebrafish [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 Objective— Prostaglandin E synthases (PGESs) are being explored as antiinflammtory drug targets as alternatives to cyclooxygenase (COX)-2. Located downstream of the cyclooxygenases, PGESs catalyze PGE 2 formation, and deletion of microsomal (m)-PGES-1 abrogates inflammation ...
Barbara Pini +2 more
exaly +3 more sources
Biochimica Et Biophysica Acta - Molecular Cell Research, 2007 Prostaglandin E2 (PGE2) is a key mediator involved in several inflammatory conditions. In this study, we investigated the expression and regulation of the terminal PGE2 synthesizing enzyme prostaglandin E synthases (mPGES-1, mPGES-2 and cPGES) in gingival fibroblasts stimulated with pro-inflammatory cytokines.
Thomas Modéer, Tulay Yucel-Lindberg
exaly +3 more sources
Expression of prostaglandin E synthases in periodontitis immunolocalization and cellular regulation. [PDF]
Am J Pathol, 2011 Båge T +12 more
europepmc +3 more sources
Frontiers in Cellular Neuroscience, 2023 Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting ...
Ayaka Hirayama +12 more
doaj +1 more source
Potent ovarian development as being stimulated by cocktail hormone in the female Scylla olivacea
Frontiers in Marine Science, 2023 The mud crab Scylla olivacea is widely cultured for its economic value, but reproduction issues limit its production. Vitellogenesis-inhibiting hormone (VIH), serotonin (5-HT), and gonadotropin-releasing hormone (GnRH) are important neurohormones that ...
Jirawat Saetan +12 more
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An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis. [PDF]
PLoS Pathogens, 2008 Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain.
Nourtan F Abdeltawab +13 more
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Regulation of cytosolic prostaglandin E synthase by phosphorylation [PDF]
Biochemical Journal, 2004 cPGES [cytosolic PG (prostaglandin) E synthase] is constitutively expressed in various cells and can regulate COX (cyclo-oxygenase)-1-dependent immediate PGE2 generation. In the present study, we found that cPGES underwent serine phosphorylation, which was accelerated transiently after cell activation.
Tsuyoshi, Kobayashi +7 more
openaire +2 more sources
Decreased PGE₂ content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. [PDF]
PLoS ONE, 2014 Varicose veins are elongated and dilated saphenous veins. Despite the high prevalence of this disease, its pathogenesis remains unclear.In this study, we investigated the control of matrix metalloproteinases (MMPs) expression by prostaglandin (PG)E₂ ...
Ingrid Gomez +6 more
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