Results 11 to 20 of about 6,192 (127)

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases [PDF]

Frontiers in Pharmacology, 2011
Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding ...
Marina eKorotkova, Marina eKorotkova, Per Johan Jakobsson   +2 more
openaire   +3 more sources

Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis. [PDF]

PLoS ONE, 2016
Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis.
Verónica García-Alonso, Esther Titos, Jose Alcaraz-Quiles, Bibiana Rius, Aritz Lopategi, Cristina López-Vicario, Per-Johan Jakobsson, Salvadora Delgado, Juanjo Lozano, Joan Clària   +9 more
doaj   +1 more source

Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E² Biosynthesis [PDF]

BMB Reports, 2005
Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties ...
Ichiro, Kudo, Makoto, Murakami
openaire   +2 more sources

Expression of Microsomal Prostaglandin E Synthase-1 in the Spinal Cord in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Journal of Pharmacological Sciences, 2012
Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still ...
Hiroko Miyagishi, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito   +3 more
doaj   +1 more source

Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 [PDF]

Trends in Cardiovascular Medicine, 2010
Both traditional and purpose-designed nonsteroidal anti-inflammatory drugs, selective for inhibition of cyclooxygenase (COX)-2, alleviate pain and inflammation but confer a cardiovascular hazard attributable to inhibition of COX-2-derived prostacyclin (PGI(2)).
Miao, Wang, Garret A, FitzGerald
openaire   +2 more sources

Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy

Journal of Diabetes Research, 2016
Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2
Lei Pang, Yin Cai, Eva Hoi Ching Tang, Michael G. Irwin, Haichun Ma, Zhengyuan Xia   +5 more
doaj   +1 more source

The involvement of miR-6615-5p/Smad7 axis and immune imbalance in ammonia-caused inflammatory injury via NF-κB pathway in broiler kidneys

Poultry Science, 2020
Ammonia (NH3), a toxic gas, has deleterious effects on chicken health in intensive poultry houses. MicroRNA can mediate inflammation. The complex molecular mechanisms underlying NH3 inhalation–caused inflammation in animal kidneys are still unknown.
Qi Han, Jianyu Tong, Qi Sun, Xiaojie Teng, Hongfu Zhang, Xiaohua Teng   +5 more
doaj   +1 more source

Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors [PDF]

Basic & Clinical Pharmacology & Toxicology, 2013
AbstractMicrosomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible terminal synthase in PGE2 biosynthesis by inflammatory and cancer cells. Clinical and experimental data emphasize that mPGES‐1 might be a valuable target, with improved selectivity and safety compared to traditional NSAIDs or selective COX‐2 inhibitors, in the treatment of ...
Marina, Korotkova, Per-Johan, Jakobsson
openaire   +2 more sources

15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Journal of Lipid Research, 2006
Prostaglandin (PG) E2 (PGE2) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE2 is accomplished by conversion of the cyclooxygenase (COX) product PGH2 by several terminal prostaglandin E synthases (PGES).
Oliver Schroäder, Yulyana Yudina, Alan Sabirsh, Nadine Zahn, Jesper Z. Haeggstroäm, Juärgen Stein   +5 more
doaj   +1 more source

Role of Microsomal Prostaglandin E Synthase 1 in the Kidney [PDF]

Journal of the American Society of Nephrology, 2007
Prostaglandin E(2) (PGE(2)) is one of the most ubiquitous prostanoids in the kidney, where it may influence a wide range of physiologic functions. PGE(2) is generated through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases (PGES).
Helene, Francois, Carie, Facemire, Anil, Kumar, Laurent, Audoly, Beverly, Koller, Thomas, Coffman   +5 more
openaire   +2 more sources