Results 11 to 20 of about 9,035 (267)

15-deoxy-Δ12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells

Journal of Lipid Research, 2006
Prostaglandin (PG) E2 (PGE2) plays a predominant role in promoting colorectal carcinogenesis. The biosynthesis of PGE2 is accomplished by conversion of the cyclooxygenase (COX) product PGH2 by several terminal prostaglandin E synthases (PGES).
Oliver Schroäder, Yulyana Yudina, Alan Sabirsh, Nadine Zahn, Jesper Z. Haeggstroäm, Juärgen Stein   +5 more
doaj   +2 more sources

Expression of Microsomal Prostaglandin E Synthase-1 in the Spinal Cord in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

Journal of Pharmacological Sciences, 2012
Prostaglandin E2 (PGE2) is a key molecule involved in the neuroinflammatory processes that characterize amyotrophic lateral sclerosis (ALS). Although PGE2 synthesis is regulated by PGE2 synthases (PGESs), the pathological role of PGESs in ALS still ...
Hiroko Miyagishi, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito   +3 more
doaj   +2 more sources

In situ imaging reveals disparity between prostaglandin localization and abundance of prostaglandin synthases

, 2021
Duncan et al. use a mass spectrometry imaging method to assess the localization and concentration of prostaglandins (PGs) in mouse tissues during pregnancy.
Erin S. Baker, Duncan, Kyle D.,, Sun, Xiaofei,, Baker, Erin S., Dey, Sudhansu K., Kyle D. Duncan, Baker, Erin S.,, Ingela Lanekoff, Duncan, Kyle D., Xiaofei Sun, Dey, Sudhansu K.,, Sudhansu K. Dey, Lanekoff, Ingela, Lanekoff, Ingela,, Sun, Xiaofei   +14 more
core   +1 more source

Microsomal Prostaglandin E Synthase-1 in Rheumatic Diseases [PDF]

Frontiers in Pharmacology, 2011
Microsomal prostaglandin E synthase-1 (mPGES-1) is a well-recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding ...
Marina eKorotkova, Marina eKorotkova, Per Johan Jakobsson   +2 more
openaire   +3 more sources

Computational Studies on Functions and Reactions of Prostaglandin Synthases [PDF]

, 2018
研究成果の概要（和文）：本研究では、プロスタグランジン類の生合成を司る酵素の機能と反応について検討した。（１）プロスタグランジンH2合成酵素(シクロオキシゲナーゼ)：本研究では、シクロオキシゲナーゼ２型の酵素(COX-2)によるアラキドン酸の水素引き抜きの段階では、活性化エネルギーが、基質の立体配座に依存することをQM/MM法で明らかにした。（２）リポカリン型プロスタグランジンD合成酵素：プロスタグランジンD合成酵素の反応について検討し ...
MORI, Seiji, 森, 聖治
core   +3 more sources

Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis. [PDF]

PLoS ONE, 2016
Obesity induces white adipose tissue (WAT) dysfunction characterized by unremitting inflammation and fibrosis, impaired adaptive thermogenesis and increased lipolysis.
Verónica García-Alonso, Esther Titos, Jose Alcaraz-Quiles, Bibiana Rius, Aritz Lopategi, Cristina López-Vicario, Per-Johan Jakobsson, Salvadora Delgado, Juanjo Lozano, Joan Clària   +9 more
doaj   +1 more source

Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E² Biosynthesis [PDF]

BMB Reports, 2005
Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase A2 enzymes, cyclooxygenase (COX) enzymes, and various lineagespecific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived PGH2 specifically to PGE2, occurs in multiple forms with distinct enzymatic properties ...
Ichiro, Kudo, Makoto, Murakami
openaire   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1 [PDF]

Trends in Cardiovascular Medicine, 2010
Both traditional and purpose-designed nonsteroidal anti-inflammatory drugs, selective for inhibition of cyclooxygenase (COX)-2, alleviate pain and inflammation but confer a cardiovascular hazard attributable to inhibition of COX-2-derived prostacyclin (PGI(2)).
Miao, Wang, Garret A, FitzGerald
openaire   +2 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source