Results 41 to 50 of about 9,035 (267)

Podocyte mPGES-2 Determines Renal Aging and Contributes to Senile Osteoporosis. [PDF]

Aging Cell
Podocyte mPGES‐2 drives renal aging through PGE2/EP1‐dependent senescence and disrupts renal endocrine support for bone homeostasis. Genetic deletion or pharmacological inhibition of mPGES‐2 protects aged mice from kidney dysfunction and osteoporosis. ABSTRACT Renal aging shortens healthspan and propagates organ dysfunction beyond the kidney, yet its ...
Zhong D, Hao C, Li M, Liu J, Xu Z, Zhou J, Zhao L, Ni S, Hu Z, Sun Y, Zou Y, Sun D, Guo H, Jia Z, Guo D, Cao JL, Sun Y.   +16 more
europepmc   +2 more sources

Avaliação da atividade do valeril salicilato, um inibidor da ciclooxigenase-1, em modelos de edema em camundongos [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O presente trabalho procurou avaliar a participação da ciclooxigenase-1 (COX-1) nos modelos de edema d e pata e ...
Siqueira Junior, Jarbas Mota
core  

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis [PDF]

Carcinogenesis, 2009
Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, and comparing with a gene signature
James J, Lee, Mitsuteru, Natsuizaka, Shinya, Ohashi, Gabrielle S, Wong, Munenori, Takaoka, Carmen Z, Michaylira, Daniela, Budo, John W, Tobias, Michiyuki, Kanai, Yasuhiro, Shirakawa, Yoshio, Naomoto, Andres J P, Klein-Szanto, Volker H, Haase, Hiroshi, Nakagawa   +13 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease [PDF]

Alzheimer's & Dementia, 2007
BackgroundThe proinflammatory prostaglandin E2 (PGE2) fluctuates over time in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin‐E synthase (mPGES)–1 have not been compared with those of normal human brains.MethodsMiddle frontal gyrus tissue from AD and ...
Uzma A, Chaudhry, Hean, Zhuang, Barbara J, Crain, Sylvain, Doré   +3 more
openaire   +2 more sources

Síntese de sulfonil-hidrazonas [PDF]

, 2003
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Derivados imidicos conhecidos ha várias décadas, têm sido amplamente utilizadas como agentes medicinais no tratamento de muitas ...
Oliveira, Kely Navakoski de
core  

Cyclooxygenase-2-derived prostaglandin E-2 protects mouse embryonic stem cells from apoptosis

, 2008
[[abstract]]Little is known about prostaglandin synthesis and function in embryonic stem cells. We postulated that mouse embryonic stem (mES) cells possess enzymes to synthesize protective prostaglandins.
Liou, JY; Ellent, DP; Lee, S; Goldsby, J; Ko, BS; Matijevic, N; Huang, JC; Wu, KK
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production.

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi Shankar, Candelario-Jalil, Eduardo, Munoz, Eduardo, Eduardo Muñoz, Michael Hüll, Lieb, Klaus, Klaus Lieb, Akundi, Ravi S., Ravi S. Akundi, Fiebich, Bernd L., Kurt Appel, Bhatia, Harsharan S., Eduardo Candelario-Jalil, Harsharan S. Bhatia, Hull, Michael, Bernd L. Fiebich, Appel, Kurt   +16 more
core   +1 more source