Results 21 to 30 of about 6,192 (127)

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BMC Genomics, 2010
Background Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα)
Modéer Thomas, Lundeberg Joakim, Lindberg Johan, Båge Tove, Yucel-Lindberg Tülay   +4 more
doaj   +1 more source

Prostaglandin E synthase is regulated in postnatal mouse testis

Frontiers in Bioscience, 2012
Prostaglandins have important roles in the male reproductive system. In this study, we report on the distribution and regulation of cPGES during postnatal development of mouse testis. The expression of cPGES was weak in testis 5 days after birth and increased through the 10th and 15th day.
Yanjun, Zhang, Yi, Du, Dengyu, Wang, Renwei, Jing, Weihua, Kong   +4 more
openaire   +3 more sources

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

Journal of Neuroinflammation, 2009
Resveratrol, a polyphenol present in grapes and red wine, has been studied due to its vast pharmacological activity. It has been demonstrated that resveratrol inhibits production of inflammatory mediators in different in vitro and in vivo models.
Candelario-Jalil Eduardo, Bhatia Harsharan S, de Oliveira Antonio, Wendeburg Lena, Fiebich Bernd L   +4 more
doaj   +1 more source

Keel Fracture Causes Stress and Inflammatory Responses and Inhibits the Expression of the Orexin System in Laying Hens

Animals, 2019
Keel fracture has negative effects on the health and welfare of laying hens. We investigated effects of keel fracture on stress, inflammation, and the orexin system in laying hens.
Haidong Wei, Chun Li, Hongwei Xin, Shuang Li, Yanju Bi, Xiang Li, Jianhong Li, Runxiang Zhang, Jun Bao   +8 more
doaj   +1 more source

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.

Arthritis research & therapy, 2005
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J   +2 more
openaire   +2 more sources

Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke

Neurotherapeutics, 2022
As the inducible terminal enzyme for prostaglandin E2 (PGE2) synthesis, microsomal PGE synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after cerebral ischemia via producing excessive PGE2. However, a proof of concept that mPGES-1 is a therapeutic target for ischemic stroke has not been established by a pharmacological ...
Lexiao Li, Nelufar Yasmen, Ruida Hou, Seyoung Yang, Jae Yeol Lee, Jiukuan Hao, Ying Yu, Jianxiong Jiang   +7 more
openaire   +2 more sources

Prostaglandin E2 involvement in the reproduction of small abalone, Haliotis diversicolor

Aquaculture and Fisheries
Prostaglandin E2 (PGE2) has been reported to be involved in reproduction as one of the most abundant and widely distributed prostaglandins in invertebrates.
Yawei Shen, Lingling Li, Xuan Luo, Miaoqin Huang, Caihuan Ke, Weiwei You, Weidong Li   +6 more
doaj   +1 more source

Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis [PDF]

Journal of Biological Chemistry, 2003
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway. Given the accumulating evidence that COX-2-derived PGE2 participates in the development of various tumors, including colorectal cancer, we herein examined the potential involvement of ...
Daisuke, Kamei, Makoto, Murakami, Yoshihito, Nakatani, Yukio, Ishikawa, Toshiharu, Ishii, Ichiro, Kudo   +5 more
openaire   +2 more sources

The crossroads of inflammation and oxidative stress: A review of the interplay between eicosanoids and reactive oxygen species

Pharmacological Research
The interplay between eicosanoids and reactive oxygen species (ROS) constitutes a bidirectional, self-amplifying ''master switch'' that drives pathophysiology ranging from inflammation to cell death.
Woo Hyun Park
doaj   +1 more source

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders

Experimental Biology and Medicine, 2023
The cyclooxygenase (COX)/prostaglandin E2 (PGE 2 ) signaling pathway has emerged as a critical target for anti-inflammatory therapeutic development in neurological diseases. However, medical use of COX inhibitors in the treatment of various neurological disorders has been limited due to well ...
Madison N Sluter, Qianqian Li, Nelufar Yasmen, Yu Chen, Lexiao Li, Ruida Hou, Ying Yu, Chao-Yie Yang, Bernd Meibohm, Jianxiong Jiang   +9 more
openaire   +2 more sources