Results 21 to 30 of about 9,035 (267)

Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy

Journal of Diabetes Research, 2016
Prostaglandin E2 (PGE2) is an endogenous lipid mediator, produced from the metabolism of arachidonic acids, upon the sequential actions of phospholipase A2, cyclooxygenases, and prostaglandin E synthases. The various biological functions governed by PGE2
Lei Pang, Yin Cai, Eva Hoi Ching Tang, Michael G. Irwin, Haichun Ma, Zhengyuan Xia   +5 more
doaj   +1 more source

The involvement of miR-6615-5p/Smad7 axis and immune imbalance in ammonia-caused inflammatory injury via NF-κB pathway in broiler kidneys

Poultry Science, 2020
Ammonia (NH3), a toxic gas, has deleterious effects on chicken health in intensive poultry houses. MicroRNA can mediate inflammation. The complex molecular mechanisms underlying NH3 inhalation–caused inflammation in animal kidneys are still unknown.
Qi Han, Jianyu Tong, Qi Sun, Xiaojie Teng, Hongfu Zhang, Xiaohua Teng   +5 more
doaj   +1 more source

Characterization of Microsomal Prostaglandin E Synthase 1 Inhibitors [PDF]

Basic & Clinical Pharmacology & Toxicology, 2013
AbstractMicrosomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible terminal synthase in PGE2 biosynthesis by inflammatory and cancer cells. Clinical and experimental data emphasize that mPGES‐1 might be a valuable target, with improved selectivity and safety compared to traditional NSAIDs or selective COX‐2 inhibitors, in the treatment of ...
Marina, Korotkova, Per-Johan, Jakobsson
openaire   +2 more sources

Role of Microsomal Prostaglandin E Synthase 1 in the Kidney [PDF]

Journal of the American Society of Nephrology, 2007
Prostaglandin E(2) (PGE(2)) is one of the most ubiquitous prostanoids in the kidney, where it may influence a wide range of physiologic functions. PGE(2) is generated through enzymatic metabolism of prostanoid endoperoxides by specific PGE synthases (PGES).
Helene, Francois, Carie, Facemire, Anil, Kumar, Laurent, Audoly, Beverly, Koller, Thomas, Coffman   +5 more
openaire   +2 more sources

Signal pathways JNK and NF-κB, identified by global gene expression profiling, are involved in regulation of TNFα-induced mPGES-1 and COX-2 expression in gingival fibroblasts

BMC Genomics, 2010
Background Prostaglandin E2 (PGE2) is involved in several chronic inflammatory diseases including periodontitis, which causes loss of the gingival tissue and alveolar bone supporting the teeth. We have previously shown that tumor necrosis factor α (TNFα)
Modéer Thomas, Lundeberg Joakim, Lindberg Johan, Båge Tove, Yucel-Lindberg Tülay   +4 more
doaj   +1 more source

Prostaglandin E synthase is regulated in postnatal mouse testis

Frontiers in Bioscience, 2012
Prostaglandins have important roles in the male reproductive system. In this study, we report on the distribution and regulation of cPGES during postnatal development of mouse testis. The expression of cPGES was weak in testis 5 days after birth and increased through the 10th and 15th day.
Yanjun, Zhang, Yi, Du, Dengyu, Wang, Renwei, Jing, Weihua, Kong   +4 more
openaire   +3 more sources

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

Journal of Neuroinflammation, 2009
Resveratrol, a polyphenol present in grapes and red wine, has been studied due to its vast pharmacological activity. It has been demonstrated that resveratrol inhibits production of inflammatory mediators in different in vitro and in vivo models.
Candelario-Jalil Eduardo, Bhatia Harsharan S, de Oliveira Antonio, Wendeburg Lena, Fiebich Bernd L   +4 more
doaj   +1 more source

Keel Fracture Causes Stress and Inflammatory Responses and Inhibits the Expression of the Orexin System in Laying Hens

Animals, 2019
Keel fracture has negative effects on the health and welfare of laying hens. We investigated effects of keel fracture on stress, inflammation, and the orexin system in laying hens.
Haidong Wei, Chun Li, Hongwei Xin, Shuang Li, Yanju Bi, Xiang Li, Jianhong Li, Runxiang Zhang, Jun Bao   +8 more
doaj   +1 more source

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.

Arthritis research & therapy, 2005
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J   +2 more
openaire   +2 more sources

Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke

Neurotherapeutics, 2022
As the inducible terminal enzyme for prostaglandin E2 (PGE2) synthesis, microsomal PGE synthase-1 (mPGES-1) contributes to neuroinflammation and secondary brain injury after cerebral ischemia via producing excessive PGE2. However, a proof of concept that mPGES-1 is a therapeutic target for ischemic stroke has not been established by a pharmacological ...
Lexiao Li, Nelufar Yasmen, Ruida Hou, Seyoung Yang, Jae Yeol Lee, Jiukuan Hao, Ying Yu, Jianxiong Jiang   +7 more
openaire   +2 more sources