Results 31 to 40 of about 6,192 (127)
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function [PDF]
Journal of Clinical Investigation, 2006 We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and stroke. These inhibitors are believed to exert both their beneficial and their adverse effects by suppression of PGHS-2-derived prostacyclin (PGI(2)) and PGE(2).
Yan, Cheng +5 more
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Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis [PDF]
Carcinogenesis, 2009 Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, and comparing with a gene signature
James J, Lee +13 more
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Elevated microsomal prostaglandin‐E synthase‐1 in Alzheimer's disease [PDF]
Alzheimer's & Dementia, 2007 BackgroundThe proinflammatory prostaglandin E2 (PGE2) fluctuates over time in the cerebrospinal fluid of patients with Alzheimer's disease (AD), but the cerebral distribution and expression patterns of microsomal prostaglandin‐E synthase (mPGES)–1 have not been compared with those of normal human brains.MethodsMiddle frontal gyrus tissue from AD and ...
Uzma A, Chaudhry +3 more
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Regulation of Cytosolic Prostaglandin E Synthase
Journal of Health Science, 2007 Biosynthesis of prostaglandin E2 (PGE2), the most common prostanoid with potent and various biological activities, is regulated by three sequential steps of cyclooxygenase (COX) pathway. We reported the molecular identification of cytosolic prostaglandin E synthase (cPGES), a terminal enzyme of the COX-mediated PGE2 biosynthetic pathway.
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Microsomal prostaglandin E synthase-1 and blood pressure regulation [PDF]
Kidney International, 2007 Prostaglandin E (PGE)(2) is a major arachidonic acid metabolite in a wide variety of tissues and is implicated in the control of inflammatory as well as physiological responses. At least three major forms of PGE synthase (PGES) have recently been cloned and characterized: membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).
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Human Microsomal Prostaglandin E Synthase-1 [PDF]
Journal of Biological Chemistry, 2003 Staffan Thorén +9 more
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