Results 31 to 40 of about 9,035 (267)

LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin Whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression [PDF]

, 2013
PMCID: PMC3711559This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Anna Nicolaou (261799), Warner, Timothy D., Louise S MacKenzie, Mitchell, JA, Nicolaou, A., Kirkby, NS, Anna Nicolaou, Jing Jiao (121723), Nicolaou, A, Urquhart, P, Zaiss, Anne K., Lundberg, Martina H., Nicolaou, Anna; id_orcid, Herschman, HR, Nicholas S. Kirkby (229832), Harvey R Herschman, Al-Yamani, Malak, Jane A Mitchell, Martina H Lundberg, Al-Yamani, M., Martina H. Lundberg (332728), Paula Urquhart, Malak Al-Yamani (432209), Mackenzie, Louise, Philip J Austin, Harvey R. Herschman (245626), Nicholas S Kirkby, Jiao, J, Herschman, H.R., Jing Jiao, Zaiss, A.K., Jiao, Jing, Kirkby, N.S., Warner, T.D., Anne K Zaiss, Lundberg, MH, MacKenzie, LS, Nicolaou, Anna, Austin, PJ, Timothy D Warner, Timothy D. Warner (200303), Philip J. Austin (432208), Al’Yamani, Malak, Urquhart, Paula, Anne K. Zaiss (432206), MacKenzie, Louise S., Urquhart, P., Lundberg, M.H., Louise S. MacKenzie (432210), Jiao, J., Paula Urquhart (432207), Mitchell, Jane A., Mitchell, J.A., Malak Al-Yamani, Mackenzie, Louise; id_orcid, Al-Yamani, M, Austin, Philip J., Herschman, Harvey R., MacKenzie, L.S., Zaiss, AK, Austin, P.J., Kirkby, Nicholas S., Jane A. Mitchell (128611), Warner, TD   +63 more
core   +1 more source

Prostaglandin E2 involvement in the reproduction of small abalone, Haliotis diversicolor

Aquaculture and Fisheries
Prostaglandin E2 (PGE2) has been reported to be involved in reproduction as one of the most abundant and widely distributed prostaglandins in invertebrates.
Yawei Shen, Lingling Li, Xuan Luo, Miaoqin Huang, Caihuan Ke, Weiwei You, Weidong Li   +6 more
doaj   +1 more source

Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis [PDF]

Journal of Biological Chemistry, 2003
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is a stimulus-inducible enzyme that functions downstream of cyclooxygenase (COX)-2 in the PGE2-biosynthetic pathway. Given the accumulating evidence that COX-2-derived PGE2 participates in the development of various tumors, including colorectal cancer, we herein examined the potential involvement of ...
Daisuke, Kamei, Makoto, Murakami, Yoshihito, Nakatani, Yukio, Ishikawa, Toshiharu, Ishii, Ichiro, Kudo   +5 more
openaire   +2 more sources

In planta recapitulation of isoprene synthases evolution from ocimene synthases [PDF]

, 2017
Isoprene is the most abundant biogenic volatile hydrocarbon compound naturally emitted by plants and plays a major role in atmospheric chemistry. It has been proposed that isoprene synthases (IspS) may readily evolve from other terpene synthases, but ...
Barbaro, E., Alberto Algarra Alarcon, Urska Vrhovsek, Claudio Varotto, Velikova, V., Loreto F, Violeta Velikova, L Cappellin, Carlin, S., Francesco Loreto, J Xu, Algarra Alarcon, A., U Vrhovsek, Xu, J., Loreto, F., Cappellin, L., Silvia Carlin, V Velikova, Li, M., Varotto, C., S Carlin, Jia Xu, Vrhovsek, U., Mingai Li, Luca Cappellin, C Varotto, Li M, Enrico Barbaro, A Algarra Alarcon, VAROTTO, CLAUDIO, E Barbaro   +30 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders

Experimental Biology and Medicine, 2023
The cyclooxygenase (COX)/prostaglandin E2 (PGE 2 ) signaling pathway has emerged as a critical target for anti-inflammatory therapeutic development in neurological diseases. However, medical use of COX inhibitors in the treatment of various neurological disorders has been limited due to well ...
Madison N Sluter, Qianqian Li, Nelufar Yasmen, Yu Chen, Lexiao Li, Ruida Hou, Ying Yu, Chao-Yie Yang, Bernd Meibohm, Jianxiong Jiang   +9 more
openaire   +2 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function [PDF]

Journal of Clinical Investigation, 2006
We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase the incidence of myocardial infarction and stroke. These inhibitors are believed to exert both their beneficial and their adverse effects by suppression of PGHS-2-derived prostacyclin (PGI(2)) and PGE(2).
Yan, Cheng, Miao, Wang, Ying, Yu, John, Lawson, Colin D, Funk, Garret A, Fitzgerald   +5 more
openaire   +2 more sources

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

The crossroads of inflammation and oxidative stress: A review of the interplay between eicosanoids and reactive oxygen species

Pharmacological Research
The interplay between eicosanoids and reactive oxygen species (ROS) constitutes a bidirectional, self-amplifying ''master switch'' that drives pathophysiology ranging from inflammation to cell death.
Woo Hyun Park
doaj   +1 more source