Results 61 to 70 of about 18,922,836 (351)
Journal of Biological Chemistry, 2001 Electrophilic eicosanoids of the J series, with their distinctive cross-conjugated α,β-unsaturated ketone, inactivate genetically wild type tumor suppressor p53 in a manner analogous to prostaglandins of the A series.
J. Mullally +3 more
semanticscholar +1 more source
Time‐Controlled Dual Targeting to Program Systemic and Intercellular Transfer of Therapeutic Effects
Advanced Functional Materials, EarlyView.Aspirin‐liposomes loaded onto monocytes enable inflammation‐triggered targeting and efficient hand‐over of aspirin to inflamed cells. Monocytes uptake a significant portion of aspirin‐liposomes, prolonging therapeutic action. This approach enhances anti‐inflammatory effects through intercellular transfer, demonstrating a translational strategy for ...
Seung Eun Yu +6 more
wiley +1 more source
Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]
, 1987 The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Koch, K. M. +3 more
core +1 more source
Prostaglandin synthesis in rat adrenocortical cells.
Journal of Lipid Research, 1979 The biosynthesis of prostaglandins by isolated rat adrenocortical cells has been studied by determinations of products formed during incubations with labeled arachidonic acid and by radioimmunoassays.
R Chanderbhan +3 more
doaj
American Journal of Clinical Nutrition, 1981 The hypothesis was tested that vitamin E protects chickens from a lethal Escherichia coli infection by inhibiting the biosynthesis of prostaglandins, thereby activating humoral immunity and phagocytosis. When chickens were fed supplement vitamin E at the
R. O. Likoff +6 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu +7 more
wiley +1 more source
Targeting Oxidative Stress Involved in Endometriosis and Its Pain
Biomolecules, 2022 Endometriosis is a common gynecological disorder seen in women and is characterized by chronic pelvic pain and infertility. This disorder is becoming more prevalent with increased morbidity.
Lauren Clower +3 more
doaj +1 more source
Regulation of renal function by prostaglandin E receptors [PDF]
Kidney International, 1998 Prostaglandin E2 is the major cyclooxygenase product of arachidonic acid metabolism produced along the nephron. This autacoid interacts with four distinct, G-protein-coupled E-prostanoid receptors designated EP1-EP4. The intrarenal distribution of each receptor has been mapped and the consequences of receptor activation examined.
Yahua Zhang +11 more
openaire +3 more sources
Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart.
Journal of Clinical Investigation, 1975 Experiments were performed to evaluate the role of prostaglandin synthesis in the regulation of coronary blood flow in dog hearts. The left main coronary artery was cannulated and flow measured both in otherwise intact animals and in canine heart-lung ...
R. Alexander +4 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang +11 more
wiley +1 more source