Results 41 to 50 of about 141,844 (309)

Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]

, 1987
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Koch, K. M., Kurtz, Armin, Kühn, K., Pfeilschifter, J.   +3 more
core   +1 more source

A single meal has the potential to alter brain oxylipin content. [PDF]

, 2020
Our objective was to determine whether consumption of a single meal has the potential to alter brain oxylipin content. We examined the cerebrum of mice fed a single high-fat/high-sucrose Western meal or a low-fat/low-sucrose control meal, as well as ...
Aung, HH, Norman, JE, Otoki, Y, Rutledge, JC, Taha, AY, Zhang, Z   +5 more
core   +1 more source

The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection.

PLoS Biology, 2021
Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL ...
Monica Cappelletti, Pietro Presicce, Ma Feiyang, Paranthaman Senthamaraikannan, Lisa A Miller, Matteo Pellegrini, Myung S Sim, Alan H Jobe, Senad Divanovic, Sing Sing Way, Claire A Chougnet, Suhas G Kallapur   +11 more
doaj   +1 more source

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Bisogno, Chiang, Cravatt, Cravatt, De Marchi, Despres, Devane, Di, Di Marzo, Di Marzo, Fernandez, Freund, Giuffrida, Giuffrida, Habayeb, Klein, Klein, Maccarrone, Matsuda, Munro, Obata, Parolaro, Pertwee, Randall, Sipe, Sparling, Sugiura, Wagner, Wagner, Walker, Yamaji   +30 more
core   +1 more source

Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla

Beilstein Journal of Organic Chemistry, 2012
Chemical defense of the invasive red alga Gracilaria vermiculophylla has been studied and compared to that of the noninvasive but related Gracilaria chilensis. Both species rely on a wound-activated chemical defense that makes them less attractive to the
Martin Rempt, Florian Weinberger, Katharina Grosser, Georg Pohnert   +3 more
doaj   +1 more source

Steroidal anti inflammatory drug betamethasone significantly alters level of striatal dopamine in a rat model of Parkinson’s disease [PDF]

, 2008
Many scientific efforts have been well done to investigate the effects of anti inflammatory agents on the degenerative brain diseases such as Parkinson’s (PD) or Alzheimer’s disease and their affiliated sings.
Amin Geravand, Hasan Mehrab, Mehdi Shafiee Ardestani, Mostafa Saffari, Nasir Mohajer   +4 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials. [PDF]

, 2014
BackgroundInhaled nitric oxide (INO), a selective pulmonary vasodilator, has revolutionized the treatment of neonatal hypoxemic respiratory failure (NHRF). However, there is lack of sustained improvement in 30 to 46% of infants.
Ambalavanan, Namasivayam, Bara, Rebecca, Cotten, C Michael, Das, Abhik, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Garg, Meena, Higgins, Rosemary D, Keszler, Martin, Klein, Jonathan M, Lakshminrusimha, Satyan, Malian, Monica, Nelin, Leif D, Ohls, Robin, Saha, Shampa, Sanchez, Pablo J, Shankaran, Seetha, Sood, Beena G, Van Meurs, Krisa P, Wallace, Dennis   +18 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source