Results 41 to 50 of about 74,807 (316)
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.
Arthritis research & therapy, 2005 Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Sampey, Annaleise V +2 more
openaire +2 more sources
Chapter 1 The prostaglandins and essential fatty acids
, 1983 Publisher This chapter discusses prostaglandins and essential fatty acids. The systematic nomenclature of prostaglandins and prostaglandin metabolites is based on prostanoic acid, a monocarboxylic acid with 20 carbon atoms, arranged as two side chains ...
Oliw, E +5 more
core +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Inhibition of glucagon-stimulated hepatic glycogenolysis by E-series prostaglandins
, 1984 The effect of E-series prostaglandins (PGE) on hepatic glucose metabolism is controversial. This study uses isolated rat hepatocytes and exogenously added PGE analogs or frequent native PGE additions (to compensate for hepatic PGE degradation) to define ...
Garrity, Maureen J. +5 more
core +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Cells, 2020 Prostaglandins are a group of physiologically active lipid compounds derived from arachidonic acid. Our previous study has found that prostaglandin E2 promotes neurite outgrowth in NSC-34 cells, which are a model for motor neuron development.
Hiroshi Nango +7 more
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Metabolism of Prostaglandins and Thromboxanes
, 1981 Around 15 years ago the first metabolic steps in the inactivation of prostaglandins were elucidated. It was demonstrated that PGs of the E and F type were extensively taken up by many organs and tissues in the body (see (1) and references therein ...
Granström, E, Elisabeth Granström
core +1 more source
Arthritis Care &Research, EarlyView.Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer +4 more
wiley +1 more source
Targeting Oxidative Stress Involved in Endometriosis and Its Pain
Biomolecules, 2022 Endometriosis is a common gynecological disorder seen in women and is characterized by chronic pelvic pain and infertility. This disorder is becoming more prevalent with increased morbidity.
Lauren Clower +3 more
doaj +1 more source