Results 41 to 50 of about 32,037,930 (259)
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Metabolism of Prostaglandins and Thromboxanes
, 1981 Around 15 years ago the first metabolic steps in the inactivation of prostaglandins were elucidated. It was demonstrated that PGs of the E and F type were extensively taken up by many organs and tissues in the body (see (1) and references therein ...
Granström, E, Elisabeth Granström
core +1 more source
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Hypoxia, bradykinin, and prostaglandins stimulate ischemically sensitive visceral afferents
, 1988 Page H556: J. C. Longhurst and L. E. Dittman. “Hypoxia, bradykinin, and prostaglandins stimulate ischemically sensitive visceral afferents.” Replace Figs. 2 B, 5 B, and 8 with the following. (See PDF) (See PDF) (See PDF)
J. C. Longhurst, L. E. Dittman
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Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Synthetic studies towards the prostaglandins
, 1978 The synthesis of an important intermediate (36) in a total synthesis of the prostaglandins was undertaken. Treatment of the monoanion of the pyrrolidine enamine of methyl acetoacetate with cis-4,5-epoxy-2(E)-decen-1-yl mesylate (42) followed by addition ...
Rickards, Gordon E.
core +1 more source
Targeting Oxidative Stress Involved in Endometriosis and Its Pain
Biomolecules, 2022 Endometriosis is a common gynecological disorder seen in women and is characterized by chronic pelvic pain and infertility. This disorder is becoming more prevalent with increased morbidity.
Lauren Clower +3 more
doaj +1 more source
Cofactors in the biosynthesis of prostaglandins F1[alpha] and F2[alpha]
, 1972 Cu2+, added to enzyme preparations from vesicular gland stimulates the production of prostaglandins F. This is further enhanced by addition of dithiols, which presumably provide reducing equivalents to convert the intermediate endoperoxide to the diol, F,
Lands, William E. M., Lee, Robert E.
core +1 more source