Results 31 to 40 of about 31,003,476 (304)

Preparation of Prostaglandin F from Prostaglandin E. Prostaglandins and Related Factors. 6. [PDF]

Acta Chemica Scandinavica, 1962
Reduction of prostaglandin E (PGE) with sodium borohydride yielded 2 compounds 1 of which is identical with PGF isolated from the prostate of sheep and the other of which had different physical and biological properties but the same elementary composition. The former was designated PGF1 and the latter PGF2.
Sune Bergström, L. Krabisch, B. Samuelsson, J. Sjövall, Olof Theander, H. Flood   +5 more
openaire   +1 more source

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation.
Kohichi, Kawahara, Hirofumi, Hohjoh, Tomoaki, Inazumi, Soken, Tsuchiya, Yukihiko, Sugimoto   +4 more
openaire   +3 more sources

Chemistry of Prostaglandins and Thromboxanes

, 1977
The structures of several prostaglandins were determined during the early 1960’s. First, two biologically active compounds were isolated from sheep vesicular glands; these compounds were called PGE1 and PGF1α (for a review, see Ref. 1). Reduction of PGE1
Granström, E, Elisabeth Granström
core   +1 more source

Metabolism of Prostaglandins

, 1977
The major initial steps in the degradation of the prostaglandins are the oxidation of the secondary alcohol group at C-15 and the reduction of the Δ13 double bond (for a recent review, see 1).
Granström, E, Elisabeth Granström
core   +1 more source

Conserved and species-specific oxylipin pathways in the wound-activated chemical defense of the noninvasive red alga Gracilaria chilensis and the invasive Gracilaria vermiculophylla

Beilstein Journal of Organic Chemistry, 2012
Chemical defense of the invasive red alga Gracilaria vermiculophylla has been studied and compared to that of the noninvasive but related Gracilaria chilensis. Both species rely on a wound-activated chemical defense that makes them less attractive to the
Martin Rempt, Florian Weinberger, Katharina Grosser, Georg Pohnert   +3 more
doaj   +1 more source

The induction of preterm labor in rhesus macaques is determined by the  strength of immune response to intrauterine infection.

PLoS Biology, 2021
Intrauterine infection/inflammation (IUI) is a major contributor to preterm labor (PTL). However, IUI does not invariably cause PTL. We hypothesized that quantitative and qualitative differences in immune response exist in subjects with or without PTL ...
Monica Cappelletti, Pietro Presicce, Ma Feiyang, Paranthaman Senthamaraikannan, Lisa A Miller, Matteo Pellegrini, Myung S Sim, Alan H Jobe, Senad Divanovic, Sing Sing Way, Claire A Chougnet, Suhas G Kallapur   +11 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2.

Arthritis research & therapy, 2005
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1 expression both in vivo and in vitro. mPGES-1 knockout studies and animal models of inflammatory arthritis also provide a strong basis for the contribution of ...
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J   +2 more
openaire   +2 more sources